Deoxyribonucleic acid mitochondrial

Bogenhagen D and Clayton DA (1974) The number of mitochondrial deoxyribonucleic acid genomes in mouse I and human hela cells. J Biol Chem 249 7991-7995. 

Goldring E.S., Grossman L.I., Krupnick D., Cryer D.R., Marmur J. (1970). The petite mutation in yeast. Loss of mitochondrial deoxyribonucleic acid during induction of petites with ethidium bromide. J. Mol. Biol. 52 323-335. 

Gross, J. F., G. S. Getz, and M. Rabinowitz. 1969. Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipid in the tissues of the rat. J. Biol. Chem., 244 1552-1562. 

Shannon, C., Enns, R., Wheelis, L., Burchiel, K., Criddle, R.S. Alterations in mitochondrial adenosine triphosphatase activity resulting from mutation of mitochondrial deoxyribonucleic acid. J. biol. Chem. 248, 3004-3011(1973)... 

DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). 

Rivera MC, Jain R, Moore JE, Lake JA (1998) Genomic evidence for two functionally distinct gene classes. Proc Natl Acad Sci USA 95 6239-6244 Saraste M, Walker JE (1982) Internal sequence repeats and the path of polypeptide in mitochondrial adp/atp translocase. FEBS Lett 144 250-254 Schatz G (1998) Protein transport - the doors to organelles. Nature 395 439-440 Schatz G, Haslbrunner E, Tuppy H (1964) Deoxyribonucleic acid associated with yeast mitochondria. Biochem Biophys Res Commun 15 127-132 Schimper AFW (1883) Ober die Entwicklung der Chlorophyll Kijrner und Farbkorner. Bot Zeit 41 105-114... 

Deoxyribonucleic acid (DNA) has limited chemical stability. As a result, oxidative damage, hydrolysis, and nonenzymatic DNA methylation occur in vivo at significant rates (L6). Thus, another aspect of this theory is that of intrinsic somatic mutations and the ability of cells to repair the damage to both mitochondrial and nuclear DNA. Indeed, mammalian cells have an elaborate system of DNA repair enzymes which become less efficient with time. Thus, failure to repair damaged DNA or to "misrepair it could lead to gene inactivation or possible excision of... 

Two nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are found in living things which serve to store, translate, and pass on the genetic information of an organism to the next generation. Nucleic acids are universal to all life, in eukaryotic and prokaryotic cells, as well as in viruses. The mitochondria of eukaryotic cells also contain some DNA, known as mitochondrial DNA. 

---