Misoprostol Propranolol

Misoprostol does not significantly alter the pharmacokinetics of propranolol. 

In 12 healthy subjects misoprostol 4(X) micrograms twice daily raised the AUC of propranolol 80 mg twice daily by about 20 to 40%, and this remained raised 7 days after misoprostol was discontinued. However, as these findings were unexpected, the authors conducted a randomised, crossover, placebo-controlled study and ensured that propranolol was at steady state before assessing the effect of misoprostol. No significant effects on the pharmacokinetics of propranolol were found. No special precautions would therefore seem necessary during concurrent use. 

Bennett PN, Fenn GC, Notarianni LJ. Potential drug interactions with misoprostol effects on the pharmacokinetics ofantip3mne and propranolol. PostgradMedJ 9ZZ ) 64 (Suppl 1), 21-4. 

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