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Miotic cells

All of the opioid agonists produce some degree of tolerance and physical dependence. The biochemical mechanisms underlying tolerance and physical dependence are unclear. It is known, however, that intracellular mechanisms of tolerance to opioids include increases in calcium levels in the cells, increased production of cAMP, decreased potassium efflux, alterations in the phosphorylation of intracellular and intranuclear proteins, and the resultant return to normal levels of release of most neurotransmitters and neuromodulators. Tolerance to the analgesic effects of opioids occurs rapidly, especially when large doses of the drugs are used at short intervals. However, tolerance to the respiratory depressant and emetic effects of the opioids occurs more slowly. The miotic and constipative effects of the opioids rarely show tolerance. [Pg.320]

It is semisynthetic vinca alkaloid. It interferes with microtubules, in miotic spindle fibres leading to cell cycle arrest... [Pg.376]


See other pages where Miotic cells is mentioned: [Pg.1568]    [Pg.508]    [Pg.537]    [Pg.281]    [Pg.107]    [Pg.406]    [Pg.803]    [Pg.545]    [Pg.655]    [Pg.634]    [Pg.521]   
See also in sourсe #XX -- [ Pg.281 ]




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Miotic

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