Minor modifications rule

A Rule 1 The minor modifications rule B Rule 2 The biological logic rule C Rule 3 The structural logic rule D Rule 4 The right substituent choice E Rule 5 The easy organic synthesis (EOS) rule... 

The minor modifications rule, even supported by prestigious results, is largely unrecognized. Making use of... 

These 49 words have formed what now is known as Hebb s Learning Rule. Although some minor modifications have been required over the years, the essence of Hebb s rule remains unchanged a memory is produced by coincident neural activity when two connected nerve cells are active simultaneously, the strength of their synaptic connection increases this confers a basis for the persistence of memory. 

With minor modification (substitution of U for T) these rules also apply to dsRNA,... 

Having seen how the evaluation of energy derivatives for fully variational wavefunctions is simplified by the 2n -i- 1 rule, let us now consider the molecular gradient for the simplest model of ab initio theory - the self-consistent field (SCF) model. We will see that, although the result for fully variational wavefunctions (equation 18) may be applied also to SCF energies, we cannot do this without first considering carefully the functional form of the energy expression. With minor modifications, the formalism presented here may be applied also to density-functional theory (DFT). 

Unfortunately, in the minds of many regulators the word laboratory may conjure up visions of fires, explosions, and highly toxic materials. For that reason, a laboratory planner should be prepared to present the proposed operation in great detail and to answer all questions, even those which may not seem relevant. Any work planned for the future should also be discussed, since the added cost of accommodating for it in the beginning may be just a fraction of what would have to be paid for later modifications. All pertinent facts must be revealed a minor omission could make a big difference in laboratory safety. A laboratory operator who has studied the various rules and regulations with care will have no problem handling such discussions. 

Details of changes to original formulations made as minor formulation modifications were documented in great detail. Now all users of the code had a consistent set of working rules. 

Prediction of metabolites is performed during initial compound upload to MetaDrug. The user specifies which metabolic rules should be applied using the Upload Structures wizard. First pass metabolites are predicted by default, however access to all rules is provided and individual rules can be selected or deselected by the user (Fig. 1). Predicted metabolites are prioritized into major, conjugated, and minor metabolite categories. An option to include second-pass metabolism for sequential modification of major metabolites is also provided. 

Unlike a biological superorganism, which may take many generations to effect even a minor hereditary modification, software is immediately modifiable and is, therefore, far superior in this respect to the biological entity in terms of evolutionary adaptability. Continuity of business rules and the physical infrastructure provides a natural tension between how fast the software can change and how rapidly the overall system can accept change. ... 

---