Eosinophilic pneumonia minocycline

Immunoallergic reactions have been reported with minocycline and include lupus-like syndrome, autoimmune hepatitis, eosinophilic pneumonia, hypersensitivity syndrome, a serum sickness-like illness (29), and Sweet s syndrome (SEDA-21, 262) (SEDA-22, 271). Over 60 minocycline-induced cases of lupus-like syndrome and 24 cases of minocycline-induced autoimmune hepatitis were found in a review of the literature (30). In 13 patients, both disorders co-existed. These patients had symmetrical polyarthralgia/polyarthritis, raised liver enzymes, and positive antinuclear antibodies they were also generally antihistone-negative, and only two patients had p-ANCA antibodies. Minocycline-related lupus can also occur in adolescents (31). 

Respiratory Acute eosinophilic pneumonia with marked neutrophilia has been attributed to minocycline [132, 133 ]. 

Sugiyama Y. Case of minocycline-induced acute eosinophilic pneumonia accompanied by marked neutrophilia in the peripheral blood. Nihon Kokyuki Gakkai Zasshi 2008 46(10) 820-4. 

Klerkx S, Pat K, Wuyts W. Minocycline induced eosinophilic pneumonia case report and review of literature. Acta Clin Belg 2009 64(4) 349-54. 

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