Minocycline comparison

Goldstein, N.S. et al., Minocycline as a cause of drug-induced autoimmune hepatitis. Report of four cases and comparison with autoimmune hepatitis, Amer. J. Clin. Pathol., 114, 591,2000. 

O Dell JR, Blakely KW, Mallek JA, Eckhoff PJ, Leff RD, Wees SJ et al. Treatment of early seropositive rheumatoid arthritis a two-year, double-blind comparison of minocycline and hydroxychloroquine. Arthritis Rheum 2001 44(10) 2235-41. 

A review of the chromatographic behavior of 90 penicillin and cephalspor-ins and their correlation to hydrophobicity has been published [339]. The current state of chromatographic methods submitted to the USP for com- plex antibiotics has been reviewed [340], A comparison has been made between poly(styrene-divinylbenzene) stationary phases and silica-based re-versed-phase sorbents for analysis of erthromycin and minocycline, and it was concluded that the nonsilica-based packings are more stable and ] reproducible [341]. The comparative retentions of ampicillin, amoxicillin,] and pencillin G was determined on Ci8, cyanopropyl-silica and poly(sty- rene-divinylbenzene), and nonbonded silica [342]. 

Naidong, W., Hua, S., Roets, E. and Hoogmartens, J. Assay and purity control of minocycline by thin-layer chromatography using UV and fluorescence densitometry—a comparison with liquid chromatography. Pharm. Biomed. Anal. 13 905-910, 1995. 

In Fig. 4.9, note the influence of creatinine clearance on the semm half life of each drug. When the creatinine clearance decreases, it is clear from the figure that the serum half life of cefazolin increases. Furthermore, it is also obvious from the figure that there is a dramatic increase in the serum half life of cefazolin when the creatinine clearance falls below 40 mL min . The semm half life of minocycline, by comparison, remains unaffected by a decrease in creati-... 

Liver In a review of 261 cases of autoimmune hepatitis, drugs were suspected in 24 cases (9.2%) [81. Nitrofurantoin and minocycline were most commonly impUcated (11 cases each). Comparison with minocychne, nitrofurantoin-induced hepatitis occurred in older patients, who had more inflammatory changes on histology, more radiological imaging abnormalities (73% versus 0%) and were more likely to have jaundice at presentation. Short-term immunosuppression was generally successful and cirrhosis did not develop. 

Raad I, Darouiche R, Hachem R, et al. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis February 1996 173(2) 418-24. Darouiche RO, Raad II, Heard SO, et al. A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. N EnglJ Med January 1999 340(l) l-8. 

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