Minirin - Desmopressin

DDAVP (Ferring) Minirin (Ferring) Desmopressin (Kyowa Hakko)... 

Lose G, Lalos O, Freeman RM, Van Kerrebroeck P, the Nocturia study group. Efficacy of desmopressin (Minirin) in the treatment of nocturia a double-blind placebo-con-trolled study in women. Am J Obstet Gynecol 2003 189 1106-13. 

Desmopressin DDAVP , Minirin , Octostim , Stimate Disopyramide... 

Its use with bradykinin and desmopressin (Zubarev et al., 1994), illustrated as a case study below, shows the benefits of MS sequence analysis. The latter peptide, desmopressin ( Minirin , a neurohypophysial hormone analogue), involves a disulphide link and a C-terminal amide, as well as a non-coded amino-acid residue (Mpa = mercaptopropionic acid) and these features can be identified by chemical sequencing methods (Chapter 5) only with considerable effort. 

Successful nasal delivery of peptide compounds has led to a number of peptide drugs being marketed for systematic absorption. These peptide drugs include buserelin (Supre-fact , Hoechst), gonadorelin (Kryptocur , Hoechst), protirelin (Relefact TRH nasal, Hoechst), calcitonin (Miacalcic , Sandoz), nafarelin (Synarel , Syntex) and desmopressin (Minirin , Ferring). Table 13.5 summarises the characteristics of some peptides studied in the nose. 

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