Minimal models tertiary protein structure

On the other hand, in a minimal catalytic model system, the ribozymes have advantages over protein enzymes. Even short oligonucleotides can effectively use duplex formation to bind substrates and the known ribozymes are generally smaller than their protein counterparts. This substrate recognition through secondary structure is not a common feature of protein binding sites, where tertiary structural folds are necessary to optimize close packing of residues distant in primary sequence [42],... 

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