Miller’s hydroxamate approach

Solid-Phase Synthesis of (3-Lactams by Miller s Hydroxamate Approach. 292... 

Scheme 42 [S-Lactams on solid phase using the Miller s hydroxamate approach...

The resulting estimated average polarizabilities for the hydroxylamines, oximes and hydroxamic acids that we have discussed are given in Table 8. (It should be noted that Miller s approach does not distinguish between oxime isomers.) As anticipated from the correlation between average polarizability and volume (equation 10), the a in Table 8 increase with molecular size. 

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