Midazolam apnea with

General anesthesia - Remifentanil is not recommended as the sole agent in general anesthesia because loss of consciousness cannot be assured and because of a high incidence of apnea, muscle rigidity, and tachycardia. Remifentanil is synergistic with other anesthetics and doses of thiopental, propofol, isoflurane, and midazolam have been... 

Use with caution in oider patients with Concurrent treatment with potent CYP 3A4 inhibitors (e.g., nefazodone) leads to increased plasma concentrations of midazolam COPD unfreafed sleep apnea... 

Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology 1990 73(5) 826-30. 

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