Microtube Plate for High-Throughput Retrieval of Compound Subsets

4 384-Microtube Plate for High-Throughput Retrieval of Compound Subsets 

The storage and retrieval of aliquots in sealed microtubes at 20 °C ensures longterm stability of the compounds that are dissolved in the frozen DMSO matrix. This sample-handling concept also minimizes the risk of compound crystallization or 

The storage of the compound collection, the assembly of the HTS library, and the retrieval of the compound subsets required for hit validation, secondary screening. 

The sample-management concept behind the three systems, their functions, and inter-connections are outlined in the following see also Tables 1 and 2. 

The Solid Sample Store is an automated sample bank facilitating storage and random access retrieval of glass vials containing powder samples. The preparation of the HTS library starts with the tedious process to prepare new solutions from the solid-compound collection. The Solid Sample Store assembles and provides the powder samples for the preparation of the HTS master solutions of defined molar concentration in pure, water-free DMSO. It is also used for the supply of powder samples to medicinal chemistry and biology labs. 

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