Microparticles permeation-enhancing

The major strategies to enhance transmucosal peptide and other drug absorption include (a) coadministration with protease inhibitors, (b) the use of membrane permeation enhancers, (c) coadministration with a combination of absorption enhancers and protease inhibitors, (d) modification of peptide structure to improve metabolic stability or membrane permeation, and (e) use of nano- or microparticles [27], Some of these strategies have been investigated using the in situ rat model. 

Cyclodextrins Natural Solubihty And Bioavailability Enhancer, Drug Stabihzation, Microparticles, Peptide Dehvery, Permeation Enhancer, Nanoparticles and Nanocapsule Sulindac, Paclitaxel Hydrocortisone... 

Thiolated chitosans, in particular, seem to be suitable for overcoming the above-mentioned drawbacks owing to their permeation-enhancing effect. To prove the efficacy of thiolated chitosans for nasal drug targeting, insulin was chosen as model dmg. Insulin-loaded chitosan-TBA microparticles were administered to the nostrils of male Wister rats, using an intravenous injection of insulin as a positive control. It was found that the absolute bioavailability of insulin loaded in chitosan-TBA microparticles was 7.24 0.76%, which was more than 3.5-fold higher than the absolute bioavailability obtained from the unmodified chitosan/insulin microparticles [78]. 

Kaukonen AM, Laitinen L, Salonen J, Tuura J, Heikkila T, LimneU T, Hirvonen J, Lehto VP (2007) Enhanced in vitro permeation of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles. Eur J Pharm Biopharm 66 348-356 Kawamura YL, Sakka T, Ogata YH (2005) Photoassisted control of Pt electrodeposition on p-type Si. J Electrochem Soc 152 C701-C705... 

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