Microorganisms marine invertebrates

The results of an antitumor screen are summarized in Table 8.1. The attrition table summarizes the results from 338,072 samples tested against tumor cells derived from soft tissue sarcomas. Given that the samples included one combinatorial collection with approximately 1.5 million compounds and that each natural product extract most likely contained 100 or more, the total number of compounds tested in this screen exceeded 5 million. As shown in the first column of Table 8.1, the samples were from 11 collections composed of single synthetics, compounds synthesized by combinatorial chemistries, and purified natural products and extracts. The natural products were derived from microorganisms (actinomyces and fungi), plants, and marine invertebrates. 

Initial screening of lipophilic and hydrophilic extracts against influenza A/WY/03/2003 (H3N2) was selected from a library of diverse marine invertebrates, algae, and microorganisms. The primary influenza screen used in this study begins with a microscopic evaluation of the cytopathic effect of extracts on virus-infected mammalian cells and is quantified by an MTT stain. From 800 screened extracts, only one, well A4 in Fig. 1.1, which is the crude extract from G. 

In summary, it has been shown that many marine invertebrates and microorganisms produce toxins which influence the environment (are allomones) and numerous, which are toxic to humans, are drug leads which are indispensable research tools for cell biology studies. 

Originally conceived for the distribution of marine invertebrates (George 1979), these zones account nicely for the distribution of the seaweeds too. The distribution of marine microorganisms... 

Since the 1950s, using a different approach, the U.S. National Cancer Institute, as well as agencies in other countries, has sought to find natural anticancer compounds in plants, fungi, microorganisms, and marine invertebrates. Among these are many antibiotics that intercalate into DNA helices, e.g.,... 

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