Integrated microfluidic systems

Excimer lasers have also been used to manufacture novel composite membranes to be used as an effective transducer for the selective transfer and sensing of molecular ions [39]. Matson et al. [40] also employed excimer laser direct patterning at 248 nm to produce membranes for solvent separators by a step and drill method but they also developed a mask patterning process to create multiple pores of small size. McNeely et al. [41] developed a rapid prototyping technique to fabricate passive hydrophobic microfluidic systems integrated with macroscopic external devices aimed at highly parallel sample analysis. Sabbert et al. [42] machined cydoolefin copolymer (COC) with no redeposition effects, smooth surface and ablation rates smaller than for PMMA using an ArF excimer laser (193 nm). 

Schwesinger, K., Erank, T, A modular microfluid system with an integrated micromixer, in Proceedings of the MME 95, pp. 144-147, Copenhagen (1995). 

H., A modular microfluid system with an integrated micromixer, J. Micromech. 

SCHWESINGER, N., FRANK, T., WURMUS, H., A modular microfluidic system with an integrated micromixer, J. Micromech. Microeng. 6 (1996) 99-102. 

J. Gao, J.D. Xu, L.E. Locascio, and C.S. Lee, Integrated microfluidic system enabling protein digestion, peptide separation, and protein identification. Anal. Chem. 73, 2648-2655 (2001). 

The hybrid integration of the IO chip with a microfluidic system is treated in detail in Sect. 10.5. 

Analysis Systems. 2. Analytical Standard Operations and Applications, Anal. Chem. 2002, 74, 2637 R. T. Kelly and A. T. Wooley, Microfluidic Systems for Integrated, High-Throughput DNA Analysis, Anal. Chem. 2005, 77, 96A ... 

M 85] [P 75] In order to determine reaction kinetics by a stopped-flow method, the mixing step within a microfluidic system was improved [161]. Traditionally, an efficient external T-channel mixer is used for this purpose. Now, the bimodal intersecting channel micro mixer was integrated into the system. The mixer has the following advantages over the current state of the art ... 

Micro Total Analysis Systems Microfluidic Aspects, Integration Concept and Applications... 

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