Microfluidic compact disc

Inganas M, Derand H, Eckersten A, Ekstrand G, Honerud AK, Jesson G, Thorsen G, Soderman T, Anders son P (2005) Integrated microfluidic compact disc device with potential use in both centralized and point-of-care laboratory settings. Clin Chem 51(10) 1985-1987... 

Lee et al. implemented a mechanical lysis device in which cells were lysed using a microfluidic filter with nanostructured barbs which they refer to as nano-knives (Di Carlo et al. [5]). Madou et al. demonstrated disruption of mammalian, bacterial, and yeast cells on a microfluidic compact disc platform using spherical beads in a lysis chamber (Kim et al. [6]). Klapperich et al. demonstrated lysis of bacteria using carbon nanotubes embedded in a porous... 

Imaad SM, Lord N, Kulsharovaa G, Liu GL (2011) Microparticle and cell counting with digital microfluidic compact disc using standard CD drive. Lab Chip 11 1448-1456... 

Keywords— microfluidic compact disc, capillary valve, flap valve, point-of-care, BioMEMS. 

N. Honda, U. Lindbeig, P. Andersson, S. Hoffman, and H. Takei, Simultaneous multiple irmmmoassays in a compact disc-shaped microfluidic device based on centrifugal force. Clinical Chemistry, vol. 51, no. 10, pp. 1955-1961, Oct. 2005. 

Honda, N., Lindberg, U., Andersson, P., Hoffman, S., andTakei, H., Simultaneous multiple immunoassays in a compact disc-shaped microfluidic device based on centrifugal force, Clin. Chem., 51, 1955, 2005. 

Moschou et al. used the compact disc microfluidic platform that is spun to allow the centripetal force to achieve pumping of the mobile phase through the channel. They incorporated a poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate-co-[2-(methacryloyloxy) ethyl] trimethylammonium chloride) monolith in the channel of a poly(dimethylsiloxane) (PDMS) chip. The unusual feature of this preparation is the use of irradiation with microwaves in a common domestic microwave oven to initiate the polymerization reaction, which is then completed in only 4.5 min. This is a significantly shorter time compared to 20 h required to obtain monolith using thermally initiated polymerization of the same mixture. This monolith was then used for the purification of enhanced green fluorescent protein in ion-exchange mode. 

Tecan Group Ltd. (Mannedorf, Switzerland) has developed LabCD, a CD format microfluidics and reaction chambers. These compact disc shaped microfluidic device can perform 48 drug screening assays simultaneously with centrifugation. 

Microfluidics allows for the miniaturization of a complete laboratory onto a compact disc (CD). Centrifugal microfluidics, or microfluidic CDs, is a unique approach to the field of microfluidics where fluids (re-agents/chemicals/clinical samples) are elegantly manipulated by rotating specialized CDs [1]. At its core, the platform only requires a spinning motor and disposable plastic disc containing a fluidic network (as shown in Figure 1). 

---