Microencapsulation techniques, formulation

The number of microencapsulated commercial oral formulations available and the volume of these formulations sold annuaUy is comparatively smaU. This may reflect the difficulty of developing new dmg formulations and bringing them successfully to market or the fact that existing microencapsulation techniques have had difficulty economically producing mictocapsules that meet the strict performance requirements of the pharmaceutical industry. One appHcation that is a particularly active area of development is mictocapsules or microspheres for oral deUvery of vaccines (45,46). 

Fig. 10). A phase separation microencapsulation technique was used to formulate nafarelin acetate in 50 50, 69 31, and 45 55 DL-lactide/glycolide copolymers (120). 

Kumar, A., Sharma, P.K., Kumar, P. Formulation of mouth dissolving tablets of glipizide by microencapsulation technique using various polymers. Biosci. Biotechnol. Res. Asia 2009, 6(1), 281-284. 

The minerals are nsed to fortify various types of products, especially bread and baked goods, breakfast cereals, dairy products, and vegetables. Moreover, they are often mixed with some vitamins and homogeneously distributed in the products. However, in some formulations, it is necessary to adopt measures to protect the micronutrients by some factors that may cause their loss or decrease of bioavailability, such as the use of microencapsulation technique. - ... 

A recent variation of the microencapsulation technique involves separating the components of the cure system by immobilizing the entire anaerobic adhesive formulation within a low-melting-point wax. The wax slurry can be applied at relatively low temperatures in the presence of oxygen and allowed to solidify in the threaded area of a fastener. Assembly with the attendant exclusion of oxygen mixes the components and initiates the curing process. 

Microencapsulation, a formulation technique much used in the pharmaceutical industry, is beginning to have limited application for farm chemicals. It consists of surrounding the toxicant with a polymeric membrane. In one example of this technique, known as interfacial encapsulation, a compatible oil-soluble toxicant... 

Kaeser-Liard, B. Kissel, T. Sucker, H. Manufacture of controlled-release formulations by a new microencapsulation process, the emulsion-induction technique. Acta Pharm. Technol. 1984, 30 (4), 294-301. 

In another report, Scher discussed pesticide microcapsules and reported that these capsules could be used to reduce mammalian toxicity, to extend activity, to reduce phytotoxicity, to protect pesticides from rapid environmental degradation, and to reduce pesticide levels in the environment [68]. Thus, many advantages are obtainable with microcapsular pesticide formulations. In an overview, Gimeno has discussed the definition of the criteria to select an active agent for microencapsulation, together with the techniques used in commercial microencapsulated formulations [69]. 

Journal of Microencapsulation 19, No.4, July-Aug.2002, p.473-84 BIODEGRADABLE BROMOCRYPTINE MESYLATE MICROSPHERES PREPARED BY A SOLVENT EVAPORATION TECHNIQUE. I. EVALUATION OF FORMULATION VARIABLES ON MICROSPHERES CHARACTERISTICS FOR BRAIN DELIVERY... 

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