Microcystis aeruginosa, plasmin inhibitors

Cyanobacteria -Microcystis aeruginosa Micropeptins 478-A and -B -peptide-based plasmin inhibitors Cyanopeptolins A-D -protease inhibitors Cyanopeptolin 963A-chymotrypsin inhibitor 120 6, 262 263... 

The prevalent Microcystis aeruginosa has afforded the plasmin inhibitors micropeptins 478-A (1115) and 478-B (1116) (1133). The terrestrial cyanobacterium Scytonema hofmanni PCC 7110 gives rise to scyptolins A (1117) and B (1118), which contain the 3-chloro-A-methyltyrosine residue (1134). The binding of 1117 to pancreatic elastase has been determined by X-ray crystallography (1135). Myriastramide B (1119) was isolated from the Philippine sponge Myriastra clavosa and features a novel chlorinated ether moiety (1136). 

Ishida K, Matsuda H, Murakami M, Yamaguchi K (1997) Micropeptins 478-A and -B, Plasmin Inhibitors from the Cyanobacterium Microcystis aeruginosa. J Nat Prod 60 184... 

Depsipeptide antibiotic. Isol. from the blue-green alga Microcystis aeruginosa. Inhibitor of plasmin and trypsin. Amorph. powder. [a]g —40 (c, 0.02 in MeOH). 

Ishida, K., Murakami, M., Matsuda, H., and Yamaguchi, K. (1995) Micropeptin 90, a plasmin and trypsin inhibitor from the blue-green alga Microcystis aeruginosa. Tetrahedron Lett., 36, 3535-3538. 

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