Scytonema hofmanni

The prevalent Microcystis aeruginosa has afforded the plasmin inhibitors micropeptins 478-A (1115) and 478-B (1116) (1133). The terrestrial cyanobacterium Scytonema hofmanni PCC 7110 gives rise to scyptolins A (1117) and B (1118), which contain the 3-chloro-A-methyltyrosine residue (1134). The binding of 1117 to pancreatic elastase has been determined by X-ray crystallography (1135). Myriastramide B (1119) was isolated from the Philippine sponge Myriastra clavosa and features a novel chlorinated ether moiety (1136). 

Matem U, Oberer L, Falchetto RA, Erhard M, Konig WA, Herdman M, Weckesser J (2001) Scyptolin A and B, Cyclic Depsipeptides from Axenic Cultures of Scytonema hofmanni PCC 7110. Phytochemistry 58 1087... 

Scyptolins A and B (Fig. 48) were isolated from axenic cultures of the terrestrial cyanobacterium Scytonema hofmanni PCC7110 by Matem et al. in 2001.They have the uncommon amino acid residue 3 -chloro-jV-methyl tyrosine and unique side chains. Both scyrtolin A and B exhibit selective inhibition of porcine pancreatic elastase in vitro with an IC50 of 3.1pg/ml l... 

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