Microbiological Production

Transglutaminases have just become recently available in larger quantities and high purity due to microbiological production of the enzyme instead of extraction from animal tissue. It can be expected that this enzyme will be used more frequently in the future for food and non-food applications. 

The final document will be reviewed and approved by various plant disciplines (engineering, microbiology, production, etc.) before the dry-heat sterilizer is considered fully validated and released for use. 

Tutova, E. G. and Kuits, P. S. (1987). Drying of Microbiological Products. Agropromizdat, Moscow (in Russ). 

Wallen, L. L., Benedict, R. G., and Jackson, R. W. 1962. The microbiological production of 10-hydroxystearic acid from oleic acid. Arch. Biochem. Biophys., 99,249-253. 

Microbiological production of citric acid can be implemented by three techniques ... 

Patentability of Natural Products, Plant Isolates, and Microbiological Products... 

Sokolova, G.A., 1960. Microbiological production of sulfur from sulfide seam waters. Mikrobiologiya, 29 888—893. 

Sanders, M.E. and Huis in t Veld, J.H.J., Bringing a probiotic-containing functional food to the market microbiological, product, regulatory and labelling issues, Antonie van Leeuwenhoek, 76, 293, 1999. 

Antimicrobial preservative content. When a preservative is required in a parenteral product, the content should be based on the lowest specified content necessary to maintain the microbiological product quality throughout its shelf life. 

Rutschmann, R. Kobel, H. Microbiological Production of Lysergic Acid Derivatives 1965 US 3,219,545... 

Several simple acids, such as oxalic and citric, were isolated from Aspergillus niger in 1891-1893. Commercial methods for the microbiological production of citric acid (1.9) were developed in the early 1920s. 

The fact that crown ethers can discriminate against tertiary amines while still moderately extracting secondary ones was applied [73,74] for the isolation of norcodeine from the biomass of its microbiological production. For example, polyorganosiloxane-linked 12-crown-4(m = 6, x = 284, y = 12) extracts 50% of norcodeine and no codeine at all. An interesting... 

Aharonowitz Y, Cohen G (1981) The microbiological production of pharmaceuticals. Scientific Amer245(3) 141-152... 

Balczewski P,Mikolajczyk M (1998) Rev Heteroatom Chem 18 37 Haneishi T, Kitahara N, Takiguchi Y, Aral M, Sugawara S (1974) J Antibiot 24 386 Haneishi T, Terehara A, Aral M (1974) J Antibiot 24 398 Hornemann U, Hopwood DA (1978) Tetrahedron Lett 19 2977 Jernow J, Tautz W, Rosen P, Williams TH (1979) J Org Chem 44 4212 Mathew J (1993) Synthetic Approaches to Methylenomycin B and Analogs. In Lukas G (ed). Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbiological Products. Springer, Berlin, Vol 2 435... 

AretzW, BerscheidHG, Huber G, Fehlhaber HW, Kraemer HP, SedlacekHH, Ganguli BN, Sood RS, Gandhi J, Reddy GC (1985) Microbiological production of anthracycline derivatives, and their cytostatic use. DE Patent 3 323 025 (Chem Abstr 102 147547)... 

Aretz W, Berscheid HG, Fehlhaber, HW, Huber G, Kraemer HP (1985) Microbiological production of antbracycline derivatives. DE Patent 3415544 (Cbem Abstr 104 107912)... 

Naylor LA, Wood JC (1999) Process for the microbiological production of pha-polymers. US Patent 5871980... 

McArthur, H.A.I. (1997) The novel avermectin, Doramectin - A successful application of mutasynthesis. Abstract S13 of the 5th International Conference on the Biotechnology of Microbiology (Products Novel Pharmacology Agrobiology Activities) Williamsburg, VA, 1997, p. 20. 

FIGURE 45.6 Dependence of constant reaction rate of thermal inactivation on temperature 9 (1) nonsporulating microorganisms (2) bacterial spores (3) antibiotics (bacitracin and grisin) and (4) lysine. (From Tutova, E.G. and Kuts, P.S., Drying of Microbiological Products, Agropromizdat, Moscow, Russia, 1987 (in Russian).)... 

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