Microbially aided synthesis

FUGANTI Microbially Aided Synthesis of Carboi fdrates... 

Whole microbial cells as well as microbially derived enzymes have played a significant role in the production of novel antibiotics. The potential of microorganisms as chemical catalysts, however, was first fully realized in the synthesis of industrially important steroids. These reactions have assumed increasing importance following the discovery that certain steroids such as hydrocortisone have anti-inflammatory activity, whilst derivatives of the steroidal sex hormones are nsefiil as oral contraceptive agents. More recently, chiral inversion of non-steroidal anti-inflammatory dmgs (NS AIDs) has been demonstrated. 

Microbial polysaccharides have been shown to stress plant cells, resulting in elicitation (induction) and increased metabolite synthesis. Induction of various enzymes has been reported. Chitosan successfully elicited chitinase production in carrot (Daucus carota) cell cultures and elicitation of desired food ingredients and processing aids via chitosan has been attempted. 

Miscellaneous - The enzymes involved in microbial cell wall synthesis " are obvious targets for the design of antimicrobial agents as a number of useful antibiotics act by inhibiting various steps in this process. The modification of penicillinase-and cephalosporinase-resistant semi-synthetic antibiotics could be aided by knowledge of the enzymology of the p-lactamases. ... 

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