Microbial iron transport compounds

Neilands, J. B. (1995). Siderophores structure and function of microbial iron transport compounds, J. Biol. Chem., 270, 26 723-26 726. 

Carrano CJ, Raymond KN (1978) Coordination Chemistry of Microbial Iron Transport Compounds. 10. Characterization of the Complexes of Rhodotorulic Acid, a Dihydroxa-mate Siderophore. J Am Chem Soc 100 5371... 

Neilands, J. B. (1973). Microbial iron transport compounds (siderochromes). In Inorganic Biochemistry (G. Eichhorn, ed.), p. 167-200. Elsevier, Amsterdam. 

Neiland JB (1981) Microbial iron transport compounds (siderophores) as chelating agents. In Martell AE, Anderson WF, Badman DG (eds) Development of Iron Chelators for Clinical Use. Elsevier/North Holland, New York p 13-31... 

Anguibactin (470) is a unique siderophore (microbial iron-transport compound) isolated from iron-deficient cultures of a fish pathogenic bacterium, Vibrio anguillarum (378). The structure of 470 was determined by X-ray diffraction studies of its anhydro derivative. Another related compound copurified with 470 was identified as 2-(2, 3 -dihydroxyphenyl)-thiazoline-4-carboxyiic acid methyl ester (471) (379). 

HPhe preceding and following chapters amply illustrate the reasons why microbial iron transport compounds are worthy of our attention—both from the biochemical and medical points of view. However, one might wonder what this has to do with coordination chemistry. The obvious answer is that these are, after all, coordination compounds. But more than that, when viewed from the perspective of a coordination chemistry, new experiments or new approaches suggest themselves. This is always the exciting potential of interdisciplinary research. This chapter is the result of a research project which has involved extensive collaboration between J. B. Neilands laboratories and my own. Many of the details of the transport studies of kinetically inert, metal-substituted siderophores in... 

Neilands, J. B., Structure of Microbial Iron Transport Compounds" in... 

K. N. Raymond, K. Abu-Dari, and S. R. Sofen, Stereochemistry of Microbial Iron Transport Compounds, in Stereochemistry of Optically Active Transition Metal Compounds , Vol. 119, ACS Symposium Series, eds. B. E. Douglas and Y. Saito, 1980, p. 7. 

Albomycins, natural siderophores and antibiotics first isolated from Streptomyces griseus and named grisein in 1947. Some years later, another microbial iron-transport compound, named albomycin, was isolated from Streptomyces subtropicus which had the same structure as grisein. In 1982, the structure of the albomycins was firmly established. The linear tripeptide built of N -acetyl-N -hydroxy-L-omithine is the hexadentate, octahedral ligand for ferric ion responsible for intraceUular transport of iron. The albomycins are used for treatment of iron metabolism disorders [G. Benz et al., Angew. Chem. Int. Ed. 1982, 21, 527 G. Benz, Liebigs Ann. Chem. 1984, 1408]. 

Neilands, J.B. Microbial Iron Transport Compounds. In Inorganic Biochemistry,... 

---