Microbial biotechnology

Sobering investigators uncovered a second significant breakthrough in microbial biotechnology of steroid production. They discovered that Corynebacterium simplex converted hydrocortisone (cortisol) (29) to prednisolone via a 1,2-dehydrogenation reaction. This A -3-ketosteroid is a highly active antiinflammatory commercial product (162). 

A third advancement in microbial biotechnology of steroid production was the abiUty to introduce a 16a-hydroxyl group microbiologicaHy (163). Modifications of the liP-hydroxylation, 16a-hydroxylation 1,2-dehydrogenation microbial processes are used for the synthesis of hydrocortisone, prednisolone, triamcinolone, and other steroid pharmaceuticals. A few microbial transformations that have been used to manufacture steroids are Hsted in Table 1 (164). 

Tyagi RD, Tran FT, Polprasert C. 1988. Bioconversion of lignosulphonate into lignin and hydrogen sulfide by mutualistic bacterial system. Journal of Microbial Biotechnology 3 90-98. 

Volumes 1—5 were originally published under the title Plant and Microbial Biotechnology Research Series.)... 

Caldwell, D. E. 1995. Cultivation and study of biofilm communities. In Microbial Biofilms (H. Lappin-Scott and J. W. Costerton, Eds.), Plant and Microbial Biotechnology Research Series 5, pp. 64-79. Cambridge Univ. Press, Cambridge, UK. 

Akino, T., Nakamura, N., Horikoshi, K. Applied Microbial Biotechnology 1987 26 323-7... 

Confronted with the often expensive methods used to synthesise nanomaterials, which involve the use of hazardous chemicals, there is a growing concern to develop environmental-friendly and sustainable methods for the synthesis of nanoparticles of different compositions, sizes, shapes, and controlled dispersity, particularly using a green chemistry approach which interconnects nanotechnology and microbial biotechnology. 

The microbial biotechnology of amino acids production which was developed and industrialized in Japan have been summarized. The amino acids include L-glutamic acid, L-lysine, L-threonine, L-aspartic acid, L-alanine, L-cysteine, L-dihydroxyphenylalanine, D-p-hydroxy-phenyl-glycine, and hydroxy-L-proline. 

Ek S (2004) Diabetes care beyond meters and strips. Roche R D Day http //www.roche.com/ pages/downloads/investor/pdf/praesentations/irp050504rdd4.pdf Elad T, Lee J, Belkin S, Gu M (2008) Microbial whole-cell arrays. Microbial Biotechnology 1 (2) 137-148... 

Microbial biotechnology, first exemplified by penicillin, yielded industrial amounts of biosynthetic compounds, followed (after the application of molecular biology) by significant numbers of microbial metabolites, engineered compounds and recombinant proteins... 

Velizarov S. (1999). Electric and magnetic fields in microbial biotechnology Possibilities, limitations and perspectives. Electro- and Magnetobiology 18 185-212. 

Feron, G. and Wache, Y., Microbial Biotechnology of Food Flavor Production, Taylor Francis Group, New York, 2006. 

At DTU, he founded and directed the Center for Microbial Biotechnology. Prof. Nielsen has published more than 350 research papers and coauthored more than 40 books, and he is inventor of more than 50 patents. He has founded several companies that have raised more than 20 mUhon in venture capital. He has received numerous Danish and international awards and is member of the Academy of Technical Sciences (Denmark), the National Academy of Engineering (USA), the Royal Danish Academy of Science and Letters, the American Institute for Medical and Biological Engineering and the Royal Swedish Academy of Engineering Sciences. 

Bansal, A.K. (2005) Bioinformatics in microbial biotechnology — a mini review. Microb. Cell Fact, 4, 19. 

Russo, R, Spano, G., Arena, M. R, Capozzi, V., Fiocco, D., Grieco, F., et al. (2010). Are consumers aware of the risks related to biogenic amines in food In A. Mendez-Vilas (Ed.), Current research, technology and education topics in applied microbiology and microbial biotechnology (pp. 1087-1095). Badajoz Formatex. 

S. I. Mussatto and J.A. Teixeira, Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology, pp. 897-907, (2010). 

Keshk, S.M.A.S., 2016. CeUulase application in enz3nnatic hydrolysis of biomass. In Gupta, V. (Ed.), New and Future Developments in Microbial Biotechnology and Bioengineering. Elsevier, pp. 185-191. ISBN 9780444635075. 

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