Microbial bioconversion

This study provides a useful reference for generating chiral alcohols by selective microbial bioconversion. 

Labuda IM, Goers KA, Keon KA (1993) Microbial bioconversion process for the production of vanillin. In Schreier P, Winterthaler P (eds) Progress in flavour precursor studies analysis, generation, biotechnology. Proceedings of the international conference, Wuerzburg. Allured, Carol Stream, pp 477-482... 

For the screening, 25 microbial cultures, obtained from the University of Mississippi Department of Pharmacognosy culture collection, were used. Microbial bioconversion studies of sarcophine (45) showed that it can be metabolized by several fungi species. Preparative-scale fermentation with Absidia glauca American-type culture collection (ATCC) 22752, Rhizopus arrhizus ATCC 11145, and R. stolonifer ATCC 24795 resulted in the isolation... 

Microbial bioconversion studies of manzamine A and ent-8-hydroxymanzamine A have shown that they can be metabolized by several microbial species.76 Preparative-scale fermentation of manzamine A with Fusarium oxysporium f. gladioli ATCC 11137 resulted in the isolation of the known ircinal A (61) as a major metabolite. Preparative-scale fermentation of enf-8-hydroxymanzamine A with Nocardia sp. ATCC 11925 and Fusarium oxysporium ATCC 7601 resulted in the isolation of the new major metabolite 12,34-oxamanzamine F (62). The latter metabolite showed no cytotoxicity against different cell lines (>10 pg/ml). 

Golovleva LA, Aliyeva RM, Naumova RP, et al. 1992. Microbial bioconversion of pollutants. Rev Environ Contam Toxicol 124 41-78. 

Labuda, I.M., Keon, K.A., and Goers, S.K. Microbial Bioconversion Process for the Production of Vanillin. In Progress in Flavour Precursor Studies (Schreier, P. and Winterhalter, P. eds.). Allured Publishing, pp. 477-482 (1993)... 

In general, more and more microbial applications are based on bioconversions, especially in the field of aroma compounds, fine chemicals, and steroid conversions. Therefore, ISPR applications for microbial bioconversions steadily increased in the 1990s (Fig. 2b). Due to the physicochemical similarity of pre-... 

Fig. 54.4 Microbial bioconversion of isoflavone 13 aglycones to isoflavone 13 glycosides...

Lysergic acid amides, most notably lysergic acid diethylamide (LSD) (37), are of interest because of their hallucinogenic activity. Microbial metabolites of LSD might serve as more active medical preparations. Another biotransformation products correspond to LSD metabolites found in humans. Both these facts led Ishii et al. (1979a,b 1980) to an extensive study of microbial bioconversions of the LSD and its derivatives. 

Xylonic acid, cf. Figure 5.3, is a sugar acid that can be obtained by the complete oxidation of xylose. It has been attempted to utilize xylose by converting it to an aldonic acid (19). Xylose was converted to xylonic acid by using commercial glucose oxidase enzyme, palladium catalysis, and microbial bioconversion. 

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