Micellar electrokinetic chromatograph resolution

Various papers related to the simultaneous determination of creatinine and uric acid can be found in the hterature. Several authors have developed capillary zone electrophoresis (CZE) methods for simultaneous analysis of these compounds in urine. The CE analysis of these renal markers offers some advantages when compared with chromatography, such as shortened separation time, reduced reagent consumption, and increased resolution. Capillar micellar electrokinetic chromatography has been applied to the simultaneous separation of creatinine and uric acid in human plasma and urine. However, chromatographic techniques are widely accepted for the determination of these compounds. Reversed-phase and ion... 

Sometimes, the addition of surfactants (at a concentration above the critical micellar concentration) can optimize the chiral resolution in CE, this improvement occurring due to the formation of a micellar phase. The chiral resolution mechanism changes slightly towards chromatographic behaviour and, therefore, this modality of CE is called micellar electrokinetic... 

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