Metoclopramide gastric motility

Effects similar to those of the neuroleptics have also been described for other dopamine-blocking agents. Thus, parkinsonism and tardive symptoms may result from use of metoclopramide, a drug which is commonly used to enhance gastric motility, or certain antiemetics, such as perphenazine. 

Pharmacology Metoclopramide stimulates motility of the upper Gl tract without stimulating gastric, biliary, or pancreatic secretions. Its mode of action is unclear. Pharmacokinetics ... 

Morphine appears to antagonise the effects of metoclopramide on gastric emptying. As a reduction in gastric motility occurs with all opioids they would all be expected to interact with metoclopramide, and other motility stimulants such as domperidone. However, these drugs are commonly used together and the clinical significance of such effects is not clear. Consider also Opioids + Antiemetics Ondansetron , below. 

A 79-year-old man underwent colonic resection for bowel obstruction. He had a history of Parkinson s disease and associated dementia, hypertension, type-2 diabetes and occasional constipation. His current medications included carbidopa-levodopa extended release, lisinopril, furosemide, isophane insulin and polyethylene glycol (as needed for constipation). He was treated with metoclopramide (10 mg i.v., every 6 h) for stimulating gastric motility. After receiving the first three doses of metoclopramide, the patient developed mental deterioration until he became xmre-sponsive, and could not be aroused. An electroencephalogram displayed a pattern of diffuse slowing of the background rhythm, which was consistent with acute metabolic encephalopathy. Metoclopramide was discontinued, and... 

Metoclopramide is a dopamine antagonist that centrally inhibits stimulation of the CTZ. By improving gastric emptying, it can decompress the stomach, thereby decreasing a peripherally associated stimulation of the emetic center. Metoclopramide may precipitate ex-trapyramidal reactions and sedation. For further details, see earlier section, Drugs that Increase GI Motility. 

DOMPERIDONE, METOCLOPRAMIDE OPIOIDS 1. i efficacy of domperidone on gut motility by opioids 2. Metodopramide T speed of onset and effect of oral morphine 1. Antagonist effect 2. Uncertain metodopramide may promote the absorption of morphine by increasing gastric emptying 1. Caution with co-administration 2. Be aware that the effects of oral morphine are T... 

Metoclopramide is an antidopaminergic/GI stimulant that stimulates upper GI tract motility, resulting in accelerated gastric emptying and intestinal transit and increased resting tone of lower esophageal sphincter. It exerts antiemetic... 

Not understood. Metoclopramide alters both the gastric emptying time and gastrointestinal motility, which can affect quinidine absorption. 

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