3-Methylvaleric acid

The carbon-chain structure of the sugar obtained from hamameli-tannin was established by the classical method of Kiliani,26 which is based on the reduction, with hydrogen iodide, of polyhydroxy acids to fatty acids. Treatment of the calcium salt of hamamelonic acid under these conditions led to inconclusive results. The reduction of the corresponding, crystalline ammonium salt, however, furnished 3.5 to 5% of 2-methylvaleric acid, which was identified by the properties of its crystalline p-iodophenacyl ester. Thus, it was proved that the sugar must have structure XIV. 

As in the case of the linear carboxylic acids, the principal by-products are water, C02 and the corresponding hydrocarbons. Substantial quantities of iso-butane are formed for example during iso-butyric acid homologation (see Experimental Section) while 2-methylpentane accompanies the formation of 2,2-dimethylvaleric acid during syngas treatment of 2-methylvaleric acid. 

Thus hydrogenolysis of coronamic acid (505) led to a mixture of isoleucine, allo-isoleucine, norleucine and 2-amino-2-methylvaleric acid this demonstrates, that all... 

Confirmation of this structure for a -D-glucosaccharinic acid was obtained by Liebermann and Scheibler when they demonstrated that the known DL-(2-methylvaleric acid) [DL-(methylpropylacetic acid)] was also formed, in low yield, in the reduction of a -D-glucosaccharinic lactone to the 2-methylvalero-l,4-lactone. Moreover, under more strenuous conditions of reduction with hydriodic acid and red phosphorus (in a sealed tube at 200°), the DL-(2-methylvaleric acid) is the principal product. 

Dimethylbutyric acid 10% 2, 3-Dimethylbutyric acid 5% 2-Ethylbutyric acid 8% 2-Methylvaleric acid 2% 3-Methylvaleric acid... 

Synthesis of the optically pure (25, 35, 4i )-4-amino-3-hydroxy-2-methylvaleric acid (18) has been achieved from L-rhamnose by conversion to 5-deoxy-L-arabino-7 -lactone (10) ° (Scheme 2)f Treatment of 10 with excess benzylamine in methanol afforded the... 

Methylvaleric acid 368 4-Phenyl-3-buten-2-ol 414 a-Terpinyl acetate... 

Smith et al. have found a new type of chiral heterogeneous catalyst based on Pt, Pd, Rh or Ru dispersed onto a >eto-cyclodextrine-epichlorohidrin copol5mier (CDP). The ability of these catalysts to catalyze the enantioselective hydrogenation of C=C bonds was tested with the hydrogenation of dimethylitaconate into dimethyl methylsuccinate and ( )-2-methyl-pent-2-enoic acid into 2-methylvaleric acid (Scheme 3.8.). 

Synonyms Ethyl 2-methylpentanoate 2-Methylvaleric acid ethyl ester Pentanoic acid, 2-methyl-, ethyl ester... 

Methyl pentanoate. See Methyl valerate 2-Methylpentanoic acid CAS 97-61-0 El NECS/ELINCS 202-594-9 UN 3265 FEMA 2754 Synonyms Methylpropylacetic acid 2-Methylvaleric acid a-Methylvaleric acid 2-Pentanecarboxylic acid Empiricai C6H12O2 Formuia CH3CH2CH2CH(CH3)COOH... 

Methylvaleric acid ethyl ester. See Ethyl 2-methylvalerate... 

Updated Entry replacing H-60192 3-Hydroxy-2-methylvaleric acid, SCI [28892-73-1]... 

Janolusimide is a tripeptide isolated from Janolus cris-tatus harvested in the Bay of Naples. This derivative is particularly unusual because it is made up of three rare or original amino adds N-methyl-L-alanine, 4-amino-3-hydroxy-2-methylvaleric acid, and a pyrroHdine-dione tri-substituted with an isopropyl group and two geminated methyl groups (Sodano and Spinella, 1986). Janolusimide is neurotoxic to the mouse, with an LD50 of 5 mgkg . Its possible biosynthesis from alanine, propionate and isobutyrate has been proposed. 

Truscott, R. J.W., Pullin, C.J., Halpern, B., Hammond, J., Haan, E. andDanks, D.M. (1979), The identification of 3-keto-2-methylvaleric acid and 3-hydroxy-2-methyl-valeric acid in a patient with propionic acidemia. Biomed. Mass Spectrom., 6,294. 

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