3.3- Dimethylbutyric acid

Koch Ro- ction. C-6-neoacids are readily available from amyl alcohols by the Koch reaction. Greater than 95% 2,2-dimethylbutyric acid [595-37-9] was obtained from 2-methyl-1-butene at 304 kPa (3 atm) CO and 35°C for 1 h with cupric oxide and sulfuric acid catalyst (31). Likewise,... 

Figure 33 Structures of (a) pivalic acid (b) 2,2-dimethylbutyric acid and (c) 1 -adamantane carboxylic acid.

Simvastatin. [lS-[la,3, 7p,8p(2S, 4S ),8a ]J-2,2-Dimethyibutanoic acid 1,2,3,7,8,8a-hexahydro-3.7 li-methy l-8-f2-( tetrahydro-4-hydroxy-6-oxo-2H-pyra rt-2-yl )-ethyl]- -naphthalenyl ester 2,2-dimethylbutyric acid 8-ester... 

Koch Reacdon. C-6-neoacids are readily available from amji alcohols by the Koch reaction. Greater than 95% 2,2-dimethylbutyric acid [595-37-9] was obtained from 2-meth5i-1-butene at 304 kPa (3 atm) CO and 35°C for 1 h with cupric oxide and sulfuric acid catalyst (31). Likewise, 2,2-dimethylbutyric acid can be obtained in high yidd (75—80%) from 1- or 2-pentanol or neopentyl alcohol from the Koch-Haaf reaction (32,33). tert-Amy. alcohol gives a mixture of trimethyl acetic acid [75-98-9] (pivalic acid), 2,2-dimeth5ibutyric acid, C-7 acids, and C-11 acids under similar Koch-Haaf conditions (33). 

See l-Hydroxy-2 2-dimethylbutyric Acid. Hydros rimethylsuccinic Acid. 

Methylcyclohexane Pentanol-2 15-25 36% 1-Methylcyclohexane-carboxylic acid-1 30% 2,2-Dimethylbutyric acid... 

Methylbutane [641] tert. Butanol 20 57 % 2,2-Dimethylbutyric acid methyl ester 1 -methylcyclohexane carboxylic acid (ratio ester to acid 1.4 1) 11 % Pivalic acid methyl pivalate... 

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