Methyltestosterone, structure

Kuuranne, T, Aitio, O., Vahermo, M., Elovaara, E. and Kostiainen, R. (2002). Enzyme-assisted synthesis and structure characterization of glucuronide conjugates of methyltestosterone (17 alpha-methylan-drost-4-en-17 beta-ol-3-one) and nandrolone (est-4-en-17 beta-ol-3-one) metabolites. Bioconjug. Chem., 13, 194-199. 

The crystal structures of 8/ -methyltestosterone 17j -bromoacetate and testosterone 17/8-p-bromobenzoate have been determined. ... 

Lit. Endocrinology 125, 2434 (1989). gen. Bohl Duax (eds.), Molecular Structure and Biological Activity of Steroids, Boca Raton CRC Press 1982 Fieser Fieser, Steroide, p. 551-587, Weinheim Verl. Chemie 1961 Zeelen, p. 177-195. - IHS293799 CASI9466-41-2 (rubro-sterone) 58-18-4 (methyltestosterone) 434-07-1 (oxymetholone) 52-78-8 (norethandrolone)]... 

Highly effective oral A, can be obtained by structural modification, e.g. methyltestosterone and mes-terolone. A. are used therapeutically, in particular to correct for deficiency symptoms following castration, hypogenitalism, impotency due to lack of hormones, climacterium, mammary carcinoma and peripheral circulatory impairment. Some synthetic testosterone analogs with a 1,2-cyclopropane ring have antiandro-genic effects. Inappropriate administration of anabolic steroids (e.g. to athletes) can lead to impotence or sterility. 

The members of this group listed in Table 31, all have a keto-group in position 3, a double bond between C atoms 4 and 5, and an OH group at the 17 position, although this is esterified in some cases. Testosterone, methyltestosterone, fluoxymesterone and methandienone are all based on the androstane structure, having methyl groups in both the 10 and 13 positions and norethandrolone and nandrolone have a methyl group at C 13 only. In addition, methandienone has a second double bond in the... 

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