4-Methylpropiophenone

Figure 9.18—NMR spectra nomenclature. The H spectrum of 3-chIoro-4-methylpropiophenone can be considered as a group of independent signals resulting from subgroups that are easily identified.

Titanium salts can also be determined using cupferron (the ammonium salt of nitrosophenylhydroxylamine) [20] or tannin [21]. In addition, 2 -hydroxy-4 -methylpropiophenone oxime has been shown to form an insoluble 1 1 complex with Ti salts [22]. 

Zhao S, Zhu M, Zhang K, Wang H, Lu J (2011) Alkaloid induced asymmetric electrochemical carboxylation of 4-methylpropiophenone. Tetrahedreon Lett 52 2702-2705... 

Also obtained by reduction of 2-chloro-2 -hydroxy-4 -methylpropiophenone with zinc powder in acetic acid [7019]. 

Obtained by reaction of methyl iodide with 5-chloro-2-hydroxy-4-methylpropiophenone in the presence of sodium ethoxide in ethanol [6488]. 

Levopropoxyphene [2338-37-6] (42), the optical antipode of the dextrorotatory analgetic propoxyphene, is an antitussive without analgetic activity. The 2-naphthalenesulfonate salt has a less unpleasant taste than the hydrochloride salt, and is widely used. Clinical effectiveness has been demonstrated against pathological and artificially induced cough, but the potency is somewhat less than codeine. The compound is reported not to cause addiction. Levopropoxyphene can be prepared (62) by first resolving [ -dimethylamino-CX-methylpropiophenone with dibenzoyl-(+)-tartaric acid. The resolved... 

Palladium-catalyzed reaction of 2-hydroxy-2-methylpropiophenone with aryl bromides shows a unique multiple arylation via successive C-C and C-H bond cleavages, giving tetraarylethanes.96 For example, the reaction of 2-hydroxy-2-methylpropiophenone with bromobenzene in the presence of Pd(OAc)2, P(/-Bu)3, and CS2CO3 gives 1,1,2,2-tetraphenylethane quantitatively, together with l,4,4-triphenyl-7-methylisochroman-3-one (13% yield) (Equation (74)). 

Hydroxy-2-methylpropiophenone (30 g., 0.183 mole) was added slowly to 150 ml. of concentrated sulfuric acid with stirring. The temperature rose and the solution turned dark brown. The temperature remained at 80° for 10 minutes and then slowly fell. After 1 hour the dark solution was poured onto 200 g. of cracked ice. The mixture was extracted with two 100-ml. portions of ether. The ethereal solution was washed with two 100-ml. portions of water, two 100-ml. portions of saturated aqueous sodium bicarbonate, and again with two 100-ml. portions of water. It was dried over anhydrous potassium carbonate, and the solvent was removed. The residue was distilled to give 18-19 g. (67-71%) of a pale yellow liquid, b.p. 65-66° (0.6 mm.) [lit2, b.p. 120° (15 mm.)], nzod 1.5510 (lit.2 n23d 1.5511) infrared band (neat) at 5.80 n (C=0). 

C10H16CINO2 2-Hydroxy-4-chloro-5- methylpropiophenone oxime Spectrophotometric u 37... 

First generation COMT inhibitors such as pyrogallol, U-0521 (3, 4-dihydroxy-2-methylpropiophenone), tropolone, and 8-hydroxy quinoline (Figure 10) were... 

FIGURE 8.8 Magnetic field dependence for the photolysis of a series of benzoyl containing molecules in cyclohexanol solution obtained by time-resolved infrared spectroscopy of the carbonyl group of the resulting benzoyl radical. Key 1 = a,a,a-trimethylacetophenone, 2 = 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, 3 = 1-benzoylcyclohexanol, 4 = 2-hydroxy-2-methy Ipropiophenone, 5 = benzoin, 6 = methyl ether benzoin, 7 = dimethyl ether benzoin, 8 = 2-dimethylamino-2-(4-methyl-benzyl)-l-(4-morpholin-4-yl-phenyl)-butan-l-one. 

For molecular precursors that produce an unsymmetrical RP, the pair members are predefined in a g-pair. However, f-pairs produced in such a reaction may be composed of any combination of the two types of radical. Figure 8.11 shows the different combinations possible. This means that the MARY dependence of f-pair MFEs must depend on the members that compose the f-pair. As the MARY curve can reveal something about the nature of its members based on the B1/2 value and the size of the LFE, the MARY curve can be used to probe the nature of the f-parr throughout the reaction period. This has recently been demonstrated for the first time for the photolysis of 2-hydroxy-4 -(2-hydro-xyethoxy)-2-methylpropiophenone in cyclohexanol. The RP has large HFCs... 

C10H12O 4-methyI-2-(1-propenyl)phenol 53889-94-4 502.76 44.150 2 19596 C10H12O2 2-hydroxy-2-methylpropiophenone 7473-98-5 504.61 44.327 2... 

Pines, S. H., Douglas, A. W. Friedel-Crafts chemistry. A mechanistic study of the reaction of 3-chloro-4 -fluoro-2-methylpropiophenone with aluminum chloride and aluminum chloride-nitromethane. J. Org. Chem. 1978,43, 3126-3131. 

Figure 6 Correlation diagram, showing the emission characteristics of propiophenone and its derivatives. The assignments of the triplet states S. are based on the lifetime and the polarization of phosphorescence. PP is propiophenone pMPP is p-methylpropiophenone pMxPP is p- methoxypropiophenone g...

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