3- Hydroxy-2-methylpropiophenone

Hydroxy-2-methylpropiophenone (30 g., 0.183 mole) was added slowly to 150 ml. of concentrated sulfuric acid with stirring. The temperature rose and the solution turned dark brown. The temperature remained at 80° for 10 minutes and then slowly fell. After 1 hour the dark solution was poured onto 200 g. of cracked ice. The mixture was extracted with two 100-ml. portions of ether. The ethereal solution was washed with two 100-ml. portions of water, two 100-ml. portions of saturated aqueous sodium bicarbonate, and again with two 100-ml. portions of water. It was dried over anhydrous potassium carbonate, and the solvent was removed. The residue was distilled to give 18-19 g. (67-71%) of a pale yellow liquid, b.p. 65-66° (0.6 mm.) [lit2, b.p. 120° (15 mm.)], nzod 1.5510 (lit.2 n23d 1.5511) infrared band (neat) at 5.80 n (C=0). 

Palladium-catalyzed reaction of 2-hydroxy-2-methylpropiophenone with aryl bromides shows a unique multiple arylation via successive C-C and C-H bond cleavages, giving tetraarylethanes.96 For example, the reaction of 2-hydroxy-2-methylpropiophenone with bromobenzene in the presence of Pd(OAc)2, P(/-Bu)3, and CS2CO3 gives 1,1,2,2-tetraphenylethane quantitatively, together with l,4,4-triphenyl-7-methylisochroman-3-one (13% yield) (Equation (74)). 

C10H16CINO2 2-Hydroxy-4-chloro-5- methylpropiophenone oxime Spectrophotometric u 37... 

First generation COMT inhibitors such as pyrogallol, U-0521 (3, 4-dihydroxy-2-methylpropiophenone), tropolone, and 8-hydroxy quinoline (Figure 10) were... 

FIGURE 8.8 Magnetic field dependence for the photolysis of a series of benzoyl containing molecules in cyclohexanol solution obtained by time-resolved infrared spectroscopy of the carbonyl group of the resulting benzoyl radical. Key 1 = a,a,a-trimethylacetophenone, 2 = 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, 3 = 1-benzoylcyclohexanol, 4 = 2-hydroxy-2-methy Ipropiophenone, 5 = benzoin, 6 = methyl ether benzoin, 7 = dimethyl ether benzoin, 8 = 2-dimethylamino-2-(4-methyl-benzyl)-l-(4-morpholin-4-yl-phenyl)-butan-l-one. 

For molecular precursors that produce an unsymmetrical RP, the pair members are predefined in a g-pair. However, f-pairs produced in such a reaction may be composed of any combination of the two types of radical. Figure 8.11 shows the different combinations possible. This means that the MARY dependence of f-pair MFEs must depend on the members that compose the f-pair. As the MARY curve can reveal something about the nature of its members based on the B1/2 value and the size of the LFE, the MARY curve can be used to probe the nature of the f-parr throughout the reaction period. This has recently been demonstrated for the first time for the photolysis of 2-hydroxy-4 -(2-hydro-xyethoxy)-2-methylpropiophenone in cyclohexanol. The RP has large HFCs... 

C10H12O 4-methyI-2-(1-propenyl)phenol 53889-94-4 502.76 44.150 2 19596 C10H12O2 2-hydroxy-2-methylpropiophenone 7473-98-5 504.61 44.327 2... 

Titanium salts can also be determined using cupferron (the ammonium salt of nitrosophenylhydroxylamine) [20] or tannin [21]. In addition, 2 -hydroxy-4 -methylpropiophenone oxime has been shown to form an insoluble 1 1 complex with Ti salts [22]. 

CAS 7473-98-5 EINECS/ELINCS 231-272-0 Synonyms HMPP 2-Hydroxy-2-methylpropiophenone 1-Phenyl-2-hy-droxy-2-methyl-propan-1 -one Classification Aromatic ketone Empirical CmHcOj Formula CeH5C0C(CH3)20H... 

Benzoyl-2-propanol HMPP a-Hydroxy-o,o,o-dimethylacetophenone o-Hydroxyisobutyrophenone 2-Hydroxy-2-methylpropiophenone a-Hydroxy-a-methylpropiophenone 1-Phenyl-2-hydroxy-2-methyl-propan-1-one 1-Propanone, 2-hydroxy-2-methyl-1-phenyl- Propiophenone, 2-hydroxy-2-methyl-Classification Aromatic ketone Empirical C10H12O2 Formula C6HsC0C(CH3)20H Properties Colorless clear to It. yel. liq. m.w. 

Figure 1 Schematic representation of the synthesis of defined SPB In the first step, a PS latex is generated, which is then covered by a thin layer of the photoinitiator 2-[p-(2-hydroxy-2-methylpropiophenone)]-ethylene glycol methacrylate (HMEM) in the second step. Photoinitiation in the presence of water-soluble monomers, such as acrylic acid, leads to polyelectrolyte chains grafted onto the surface of the core particles in the third step. Taken with permission from Ballauff, M. Macromol Chem. Phys. 2003, 204, 220. ...

The synthesis of PS core particles by emulsion polymerization and polyelectrolyte brushes by photopolymerization was first reported by Ballauff and co-workers in 1999. Figure 1 displays this route schematically First, nearly monodisperse PS cores are made by conventional emulsion polymerization. Then a thin layer of a suitable photoinitiator is polymerized onto the surface of these cores. The photoinitiator, 2-[p-(2-hydroxy-2-methylpropiophenone)]-ethylene glycol methacrylate... 

Preparation by reaction of iodine and iodic acid with 2-hydroxy-5-methylpropiophenone in dilute ethanol for 1.5 h at 35-40° (86%) [6366]. 

Preparation by reaction of concentrated nitric acid (d = 1.42) with 4-hydroxy-2-methylpropiophenone in acetic acid [6994]. 

Also obtained from 5-tert-butyl-2-hydroxy-3-methylpropiophenone by tert-butyl group elimination with aluminium chloride (2 equiv) at 190° for 15 min (77%) [6466],... 

Also obtained by treatment of 5-tert-butyl-4-hydroxy-2-methylpropiophenone with aluminium chloide at 200° fw 15 min (40%) [7025]. There are first a tert-butyl group elimination, followed by an acyl group migration fiom para to ortho positim. 

Also obtained by reduction of 2-chloro-2 -hydroxy-4 -methylpropiophenone with zinc powder in acetic acid [7019]. 

Also obtained by isomerization of 4-hydroxy-2-methylpropiophenone with aluminium chloride (3 mol) for 1 h at 180-200° (43%) [6482],... 

Preparation from 3-iodo-2 -hydroxy-5 -methylpropiophenone by treatment with zinc powder in 80% acetic acid and heating on a water bath [7043]. 

Also obtained by treatment of 2-hydroxy-3-isopropyl-6-methylpropiophenone with aluminium chloride (1.4 equiv) without solvent at 100° for 2 h (25%) [7026]. 

Preparation by reaction of diethyl sulfate with 2-hydroxy-5-methylpropiophenone in the presence of sodium hydroxide [7055],... 

Obtained by reaction of methyl iodide with 5-chloro-2-hydroxy-4-methylpropiophenone in the presence of sodium ethoxide in ethanol [6488]. 

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