4-methylphenyl 2- phenyl

Meclizine Meclizine, l-[(4-chlorphenyl)methyl]-4-[(3-methylphenyl)phenyl]piperazine (16.1.16), is synthesized by reductive amination of a mixture of 3-methylbenzaldehyde with l-(4-chlorbenzhydryl)piperazine using hydrogen over Raney nickel [27-29]. 

For instance, the relative oxidizing ability of Ar3BiCl2 (in the Ar3BiCl2/DBU system) was found to be in the order Ar = /j-nitrophenyl > /j-(trifluoromethyl) phenyl > o-methyl-p-chlorophenyl > p-chlorophenyl > o-methylphenyl > phenyl > p-methylphenyl. On the basis of these findings, new efficient triarylbismuth(V) oxidants have been prepared and some reagents are now commercially available. 

Although the preparation has been repeated, there have been no other reports of the type of reaction, (described in 1923) in which carbazole in the presence of excess potassium hydroxide and nitrobenzene at only 50°C gave a good yield of 9-(4-nitrophenyl)-carbazole, presumably via an adduct such as 43 subsequently oxidized by excess nitrobenzene and/or air. More recent examples of N-arylation of carbazoles have involved copper catalysis in reaction of aryl halides with carbazoles. Thus, copper bronze and potassium carbonate heated with the carbazole and the appropriate aromatic halide have produced 9-(4-methoxyphenyl)- and 9-(2-tolyl)carbazoles 9-(4-phenylphenyl)carbazole, l,4-di(carbazol-9-yl)benzene, 4,4 -di(carbazol-9-yl)biphenyl, and 9-(2-pyridyl)- and 9-(2-quinolyl)carbazoles 9-[2-(2-phenylphenyl)phenyl]- and 9-[2-(4-methylphenyl)phenyl] carbazoles 9-(3-bromo-6-nitrophenyl)-, 9-[3-(carbazol-9-yl]-, 9-(2-nitrophenyl)-, 9-(4-methyl-2-nitrophenyl)-, 9-(4-methoxycarbonyl)-l-nitro-, and l-nitro-9-(4-tolyl)carbazoles 9-(2-methoxycarbonylphenyl)carbazole 9-[2- 2-... 

D-Galactose methylphenyl-phenyl-osa-zone anhydride, III, 34 D-Galactose methylphenyl-phenyl-osa-zone tetraacetate, III, 34 D-Galactoae p-nitrophenylhydrazone, III, 26... 

A detailed analysis of the NMR spectra of the product obtained from phenyl tellurium bromide and 4-methylphenyl magnesium bromide revealed that diphenyl tellurium and bis[4-methylphenyl] tellurium had been formed in addition to the expected unsymmetrical compound. Pure 4-methylphenyl phenyl tellurium was obtained with stoichiometrically insufficient amounts of bromine and Grignard reagent5. 

Bis[4-methylphenyl Phenyl Tellurium Bromide] Oxide1 1.5 g (4.3 mmol) of 4-methylphenyl phenyl tellurium hydroxide chloride (or dichloridc) are dissolved in water and potassium bromide is added. The precipitate is collected and recrystallized from 600 ml of water m.p. 260°. 

Methylphenyl phenyl tellurium bis[methanesulfonate] was isolated when the diaryl tellurium dibromide and silver methanesulfonate were reacted in dry benzene. After filtration, the reaction mixture was frozen and the frozen solvent removed in a vacuum. ... 

When this reaction was carried out in methanol, when the diaryl tellurium oxide was combined with methanesulfonic acid, or when the disulfonate was heated at 140°, bis[4-methylphenyl phenyl methanesulfonate tellurium] oxide was obtained1. 

The reported preparation of 4-methylphenyl phenyl tellurium bis[t/-bromocamphorsulfo-nate] from the diaryl tellurium dibromidc and the silver sulfonate in acetone2 was found to be irreproducible. Only non-crystalline, non-uniform mixtures were obtained1. 

Reaction of a diaryl tellurium dibromide with silver methanesulfonate in methanol, reaction of a diaryl tellurium oxide with methanesulfonic acid, or heating of a diaryl tellurium disulfonate at 140° gave bis[methylphenyl phenyl methanesulfonato tellurium] oxide2. 

Attempts were made to resolve triorgano telluronium iodides with three different organic groups bonded to the tellurium atom into optically active isomers Methyl 4-methylphenyl phenyl telluronium iodide was treated with optically active camphorsulfo-nates . The isolated telluronium camphorsulfonates showed mutarotation indicating that the telluroniiun cation had been at least partially resolved. Treatment of the telluronium camphorsulfonates with potassium iodide yielded the racemic telluronium iodides. ... 

---