Methylphenidate developmental disorders

Recent open and double-blind studies indicate that methylphenidate can help a subset of autistic hyperactive children, particularly those with IQs >45, by decreasing ADHD-like symptomatology without increasing stereotypies, tics, or anxiety (Birmaher et ah, 1988 Aman et ah, 1993, 1997 Quintana et al. 1995 Handen et al., 1999). While some patients with pervasive developmental disorders (FDD) experienced adverse reactions to stimulants, the majority of them had IQs of <45 (Handen et al., 1999). 

Research Units on Pediatric Psychopharmacology Autism Network (2005a) Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry 62 1266-1274. 

A 6-year-old girl with ADHD and pervasive developmental disorder and behavioural problems who was treated with Depakote (valproic acid) and had an abnormal electrocardiogram (ECG) with left Centro parietal spikes experienced a convulsion the day after the first administration of a methylphenidate dose. A repeat electroencephalography demonstrated continuous spike and slow wave during sleep [73 ]. 

ADHD, attention-deficit hyperactivity disorder DD, developmental disabilities DEX, dexedrine MPH, methylphenidate N, total number of subjects in entire study n, number of preschool-age subjects in study SE, side effect. 

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