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Methylphenidate analogues

Deutsch HM, Shi Q, Gruszecka-Kowalik E, et al. Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogues. J Med Chem 1996 39 1201-1209. [Pg.968]

Slow-onset, long duration dopamine reuptake inhibitors with reduced potential for substance abuse have been suggested as therapies for psychostimulant addiction [33-35]. A series of slow-onset, long duration N-alkyl analogues of methylphenidate were recently reported to have enhanced selectivity for the dopamine transporter [34]. A representative compound is 13, an RR/SS diastereomer (DAT K, = 16nM, SERT K = 5900 nM, NET K-, = 840 nM). In a locomotor activity assay in mice, 13 has a slow onset of activity (20-30 min) with peak activity occurring between 90 and 120 min. In contrast, both methylphenidate and cocaine are active within 10 min and reach peak activity within 30 min. [Pg.17]

Methylphenidate increased some of the motor effects of levodopa in selected patients with Parkinson s disease (52). Changes in self-assessed analogue ratings of mood, anxiety, arousal, or concentration did not differ. [Pg.2311]

Ma huang, "herbal ecstasy," other phenylpropanolamine analogues Nicotine and withdrawal, anabolic steroids, narcotic withdrawal, methylphenidate, phencyclidine, ketamine, ergotamine and other ergot-containing herbal products, St. John s wort Food Substances Sodium ... [Pg.186]

Methylphenidate (Ritalin) was fortified in human urine samples and extracted by liquid-liquid extraction. A trideuterated analogue of methylphenidate (methylphenidate- ) was used as an internal standard for the analysis. The detailed sample preparation procedure is described elsewhere.13 The final samples containing both methylphenidate and methylphenidate- were in 75% methanol, 25% water and 0.1% formic acid. [Pg.142]

Kim DI, Deutsch HM, Ye XC, Schweti MM. Synthesis and pharmacology of site-specific cocaine abuse treatment agents Restricted rotation analogues of methylphenidate. / Med Chem. 2007 50 2718-2731. [Pg.387]


See other pages where Methylphenidate analogues is mentioned: [Pg.240]    [Pg.301]    [Pg.2]    [Pg.841]    [Pg.355]    [Pg.356]   
See also in sourсe #XX -- [ Pg.354 , Pg.355 , Pg.355 ]




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