Methylmercaptopurine riboside

SYNS 6-METHYLMERCAPTOPURINE RIBONUCLEO-SIDE 6-METHYLMERCAPTOPURINE RIBOSIDE 6-METHYL-9-RIBOFURANOSYLPURINE-6-THIOL 6-METHYL-MP-RIBOSIDE 6-METHYLTHIOINOSINE 6-(METHYLTHIO)PURINE RJBONUCLEOSIDE 6-METHYLTHIOPURINE RIBOSIDE NCI-C04784 NSC-40774 P-d-RIBOSYL-6-METHYLTHIOPURINE SQ 21977... 

Purine and Pyrimidine Analogues - The following comments will center upon work published in 1966 Heidelberger has included earlier work in this area in his recent review. Modifications of 6-mercaptopurine (I) are of continuing interest because of mereaptopurine s activity in human leukemia, and the ultimate development of resistance by the leukemic cells to this drug. 6-methylmercaptopurine riboside (II) is converted to 6-methyImercaptopurine ribonucleotide (III) by a nucleoside kinase. Cells... 

C1iH1SCIN3O5S, 2,2 -Anhydro-1-/3-D-arabinofuranosyl-5-dimethylsul-phonio-6-oxocytosine chloride, 45B, 497 CiiHisN20bS, 2-Thio-5-carboxymethyluridine monohydrate, 44B, 424 Cl iHi sNijObS, 6-Methylmercaptopurine-riboside monohydrate, 42B, 346 CiiHigNsOgP 0.5 HjO, Adenosine 5 -methylphosphonate hemihydrate, 45B, 498... 

The leukemia treatment drug 6-meicaptopurine and seven metabolites (e.g., 6-methylmercaptopurine, 6-mercaptopurine riboside, 6-thioguanosine, 6-thioxanthine) were extracted from plasma and separated on a C g column (2 = 295 nm and 330nm). A 50-min 90/10 (hold lOmin) 0/100 (at 50min) 98/2 water [30mM ammonium phosphate pH 3]/methanol)/(60/40 water [30 mM ammonium phosphate pH 3]/methanol) gradient was used [517]. Detection limits were reported as 20-50 nM (analyte dependent). 

---