Leukemia treatments

The proportion of ALL in patients older than age 60 years constitutes between 16% and 31% of all adult leukemias. Treatment of adults largely has followed the conventional chemotherapeutic regimes used in childhood ALL. However, the intensification regimens common in childhood are not suitable for this population because of their associated toxic-ities in older patients. The adverse prognostic factor, the Philadelphia chromosome, occurs in 15% to 30% of adults and thus is more common in the over 60 age group.17 Based on the experience achieved in CML, the use of imatinib, a potent inhibitor of the Ph+-associated BCR-ABL tyrosine kinase, is becoming a common practice for these older adults. Results show that the combination of imatinib with conventional chemotherapy has improved remission rates compared with the use of conventional chemotherapy alone,... 

Riehm H, Gadner H, Henze G. Acute lymphoblastic leukemia treatment results in three BFM studies (1970-1981). In Leukemia research advances in cell biology and treatment. (Murphy SB, Gilbert JR, eds.), Amsterdam Elsevier Science Publishing, 1983 251-163. 

Role of the Folate-Pathway and the Thymidylate Synthase Genes in Pediatric Acute Lymphoblastic Leukemia Treatment Response... 

Jenks S, Smigel K. Updates cancer drug approved new leukemia treatment. J. Nat. Cancer Inst. 1995 87 167-170. 

Eqns. (18.6) are integrated between the time of release and infinite time. If infinity is considered unreasonable, one uses "truncated time" e.g. for a person it may be 70 years, while for the human population a common figure of500 years is often used. It is sometimes claimed in such calculations that improvements in medical science are incorporated (e.g. improved leukemia treatments reduce mortality probabilities). 

Disease (GvH D) in donor lymphocyte transfer for leukemia treatment gene of the herpes simplex virus, followed by treatment with Ganciclovir vectors ex vivo treatment of host-vers us-graft disease... 

Stecher, A.L. et ah. Stability of L-asparaginase An enzyme used in leukemia treatment, Pharm. Acta Helv., 74, 1, 1999. 

About 200,000 people currently live with leukemia in the USA, with about 35,000 new cases and 23,000 deaths each year. Leukemia treatment typically involves high doses of chemotherapy, which kill both cancerous cells and bloodregenerating marrow progenitors. To restore bone marrow function after therapy, physicians... 

The leukemia treatment drug 6-meicaptopurine and seven metabolites (e.g., 6-methylmercaptopurine, 6-mercaptopurine riboside, 6-thioguanosine, 6-thioxanthine) were extracted from plasma and separated on a C g column (2 = 295 nm and 330nm). A 50-min 90/10 (hold lOmin) 0/100 (at 50min) 98/2 water [30mM ammonium phosphate pH 3]/methanol)/(60/40 water [30 mM ammonium phosphate pH 3]/methanol) gradient was used [517]. Detection limits were reported as 20-50 nM (analyte dependent). 

Cunningham I, Gee T, Reich L (1989) Acute promyelocytic leukemia treatment results during a decade at Memorial Hospital. Blood 73 1116-1122... 

---