Methylene chloride toxicity data

When a solution is tested, both analyte and solvent absorption bands will be present in the spectrum, and identification, if that is the purpose of the experiment, is hindered. Some solvents have rather simple IR spectra and are thus considered more desirable as solvents for qualitative analysis. Examples are carbon tetrachloride (CC14, only C-Cl bonds), choloroform (CHC13), and methylene chloride (CH2C12). The infrared spectra of carbon tetrachloride and methylene chloride are shown in Figure 8.21. There is a problem with toxicity with these solvents, however. For quantitative analysis, such absorption band interference is less of a problem because one needs only to have a single absorption band of the analyte isolated from the other bands. This one band can be the source of the data for the standard curve since the peak absorption increases with increasing concentration (see Section 8.11 and Experiment 25). See Workplace Scene 8.2. 

NIOSH REL (Methylene Chloride) Reduce to lowest feasible level DOT CLASSIFICATION 6.1 Label KEEP AWAY FROM FOOD SAFETY PROFILE Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects by ingestion and inhalation paresthesia, somnolence, altered sleep time,... 

Definition Polymer of ethylene oxide Formula H(OCH2CH2)nOH, avg. n = 150 Properties Creamy-wh. flakes or powd., waxy paraffin-like appearance very sol. in water, methylene chloride pract. insol. in alcohol, ether, fatty and min. oils m.w. 5600-7000 dens. 1.21 (25/25 C) vise. 470-900 cSt (210 F) m.p. 56-63 C hyd. no. 16-22 flash pt. > 887 F nonionic Toxicoiogy LDLo (oral, rat) 50 g/kg LD50 (IP, rat) 6790 mg/kg mildly toxic by ing. skin irritant mutagenic data TSCA listed Precaution Combustible exposed to heat or flame... 

Toxicity Data for Methylene Chloride and Ethyl Acetate ... 

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