Methylamphetamines

Verster, J., and Van Praag, H.M. A comparative investigation of methylamphetamine and 4-chloro-N-methylamphetamine in healthy test subjects. Pharmako-Psychiatric Neuropsychopharmacologie 3 239-248, 1970. 

Seiden, L.S., and Vosmer. G. Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine. Pharmacol Biochem Behav 21 29-31, 1984. 

Commins, D.L., and Seiden, L.S. Alpha-methyltyrosine blocks methylamphetamine-induced degeneration in the rat somatosensory cortex. Brain Res 365 15-20, 1986. 

Finnegan, K.T. Rieaurte, G. Seiden, L.S. and Schuster, C.R. Altered sensitivity to rhesus monkeys depleted of eaudate dopamine by repeated administration of (7-methylamphetamine. Psychopharmacology 77 43-52, 1982. 

Lucot, J.B. Wagner, G.C. Schuster, C.R. and Seiden, L.S. The effects of dopaminergic agents on the locomotor activity of rats after high doses of methylamphetamine. Pharmacol Biochem Behav 13 409-413, 1980. 

Ricaurte, G.A. Guillery, R.W. Seiden, L.S. Schuster, C.R. and Moore, R.Y. Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain. Brain Res 235 93-103, 1982. 

Cheng, H.C. Long, J.P. Nichols, D.E. and Barfknecht, C.F. Effects of psychotomimetics on vascular strips Studies of methoxylated amphetamines and optical isomers of 2,5-dimethoxy4-methylamphetamine and 2.5-dimethoxy-4-bromoamphetamine. J Pharmacol Exp Ther 188 114-123, 1974. 

Silverman, P.B., and Ho, B.T. The discriminative stimulus properties of 2,5-dimethoxy-4-methylamphetamine (DOM) Differentiation from amphetamine. Psychopharmacology (Berlin) 68 209-215, 1980. 

Berger, U. Hung, G. Molliver, M.E. and Grzanna, R. Psychotropic amphetamines have different sites of action at serotonergic (5-HT) synapses A eomparison of p-chloroamphetamine (PCA) and 3,4-methyl-enedioxyamphetamine (MDA) with 2,5-dimethoxy-4-methylamphetamine (DOM). Abstr Soc Neurosci 13 906, 1987. 

Rollema, J. De Vries, J.B. Westerink, B.H.C. Van Putten, F.M.S. and Horn, A.S. Failure to detect 6-hydroxy dopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP. Eur J Pharmacol 132 65-69, 1986. 

Commissaris, R. L., Lyness, W. H., Cordon, J. J., Moore, K. E., and Rech, R. H. (1980) The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM) and d-amphetamine on operant responding in control and 6-hydroxydopamine-treated rats. Pharmacol. Biochem. Behav., 13 621-626. 

Harvey, J. A., Gormezano, I., and Cool, V. A. (1982) Effects of d-lysergic acid diethylamide, d-2-bromo-lysergic acid diethylamide, d-l-2-5-dimethoxy-4-methylamphetamine and d-am-... 

Snyder, S. H., Weingartner, H., and Faillace, L. A. (1970) DOET (2,5-dimethoxy-4-ethylam-phetamine) and DOM (STP) (2,5-dimethoxy-4-methylamphetamine), new psychotropic agents Ther effects in man. In Psychotomimetic Drugs, edited by D. Efron, pp. 247-264. Raven Press, New York. 

It is probably best to avoid p-methoxyamphetamine (PMA) and 2,5-dimethoxy-4-methylamphetamine (STP), the former because it seems to have a high toxicity and the latter because it lasts too long (e.g., 24 hours for a minimum dose). Other 4-alkyl amphetamines also seem to be toxic. A number of apparent fatalities due to MDA have been noted, but the reports usually involve very large amounts, often in combination with other drugs (e.g., 7 g MDA plus barbiturates) and screening for other, more toxic drugs (in particular, PMA) has not been done. 

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