1 -Methyl-5-methylsulfonyl-4-nitro

Die Umsetzung von l-Methyl-4-methylsulfonyl-5-nitro-imidazol mit Cyanid fuhrt ebenfalls analog der entsprechenden Reaktion der Halogen-Derivate (s.S. 162) nicht, wie zu erwarten, zu 4-Cyan-l-methyl-5-nitro-imidazol, sondern zu 5-Cyan-l-methyl-4-nitro-imidazol961. 

S atranidazole (1 -methylsulfonyl-3 -(1 -methyl-5-nitro-2-imidazolyl)-2-imidazo-lidinone) is reduced more easily at pH 7 and is more sensitive to pH than other nitroa-zoles (Table 3.42). Based on the comparison of the reduction potentials of satranidazole (at pH 7) with the potentials of 5-nitro- and 2-nitroimidazole derivatives and on the... 

The transformation of l-methylthio-l-(methylsulfonyl)alkanes (254) to methyl esters can be efficiently carried out by oxidation or by a-chlorination followed by methanolysis (equation 152)145. The lithium or the sodium salt of (phenylsulfonyl)nitromethane (256) is a very useful reagent for the preparation of higher homologues of nitromethanes by alkylation since the salts are air insensitive, non-hygroscopic, and easily handled without decomposition. The oxidation of the resulting secondary a-nitro sulfone (257) gives... 

Methyl 6-methyl-2,3-dioxo-1,2,3,4-tetrahydro-5-quinoxalinecarboxylate 2-Methyl-3-methylene-7-methylsulfonyl-4-phenyl-3,4-dihydroquinoxaline 2-Methyl-3-methylene-7-nitro-4-phenyl-3,4-dihydroquinoxaline... 

To increase further the effect they prepared analogues of compound 37, in which one of the three methyl groups of the trimethyl moiety was substituted by an electronegative group such as an alkoxy, methylmercapto, methylsulfinyl, methylsulfonyl, cyano, nitro or azo group. Among these, 2-methyl-2-methyl-mercaptopropionaldehyde-O-methylcarbamoyl oxime, (38), known under the common name aldicarb, proved to be the most efficient. 

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