Methyl chloride ethoxy

The procedure was proved to be general for the preparation of protected hydroxy acids from lactones (121). This apparently trivial process is often difficult to carry out, as the attempted derivatization of y or J-hydroxyacids frequently results in relactonization rather than hydroxyl protection. The method was applied to several aldonolactones to produce the corresponding intermediate hydroxyamides. Protection using [(2-trimethylsilyl)-ethoxy]methyl chloride, methoxymethyl chloride, ter/-butylchlorodimeth-ylsilane, or zm-butylchlorodiphenylsilane followed by ozonolysis gave the protected N-(y- or <5-hydroxyacyl)indole derivatives. Mild saponification gave indole and the acetal- or silyl-protected hydroxy acids. 

Magnesinm (2-Chlor-ethoxy)-methyl- -chlorid XIII/2a, 115... 

SYNS CHLOROMETHOXY ETHANE ETHOXY CHLOROMETHANE ETHOXY METHYL CHLORIDE... 

ETHOXYMETH YNE see EMTOOO ETHOXY METHYL CHLORIDE see CIMOOO ETHOXYMETHYLENEMALONIC ACID, ETHYL ESTER see EEV200... 

Additional chemical evidence for the assignment of the 58 ppm resonance to the methoxy species III was the observation that it also formed from methyl bromide and methyl chloride in relative yields consistent with the leaving group stability T > Br > Cl. Methyl iodide was adsorbed on several zeolites with different Si/Al ratios, and the intensity of the 58 ppm resonance correlated with the A1 content, as it must for a framework-bound alkoxy. The final example of chemical evidence for the assignment regards the expected chemistry of species such as III and VI upon exposure to moisture. The Si-O-C linkage is easily hydrolyzed on a silica gel surface to form alcohols and/or ether. As demonstrated in Fig. 16, the species assigned to III readily hydrolyzes to methanol and dimethyl ether, whereas the proposed ethoxy species formed from ethyl iodide- C hydrolyzed to ethanol upon exposure to atmospheric moisture. 

Sodium acid methanearsonate Methane base. See Bis (p-dimethylaminophenyl) methane Methane, bis (2-(2-butoxyethoxy) ethoxy)-. See Butylcarbitol formal Methanebis (N,N -(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol). See Imidazolidinyl urea Methane, bromochloro-. See Bromochloromethane Methane, bromochlorodifluoro-. See Bromochlorodifluoroemethane Methane, bromodichloro-. See Bromodichloromethane Methane, bromotrifluoro. See Trifluorobromomethane Methanecarbonitrile. See Acetonitrile Methanecarboxamide. See Acetamide Methanecarboxylic acid. See Acetic acid Methane, chloro-. See Methyl chloride Methane, chlorodibromo-. See Chlorodibromomethane Methane, chlorofluoro-. See Chlorofluoromethane Methane, compressed. See Methane gas, Methane cyanine. See Malononitrile Methane, diazo-. See Diazomethane Methanedicarbonic acid Methanedicarboxylic acid. See,Malonic acid Methanedicarboxylic acid, diethyl ester. See Diethyl malonate... 

A vigorously stirred mixture of trichloroacetyl chloride and dry pyridine cooled to —10° under N2, ethyl vinyl ether added, and stirring continued for 12 h at 0-25° -> l,l,l-trichloro-4-ethoxy-3-buten-2-one (Y 92-7%), added dropwise to a stirred mixture of K2CO3 and dry methanol over 30 min with cooling, and stirred at room temp, for 10 h methyl 3-ethoxy-3-methoxypropanoate (Y 80%). F..e.s. L.-F. Tietze et al., Synthesis 1988, 274-7. 

A mixture of morpholino-(4-dilorophenylimino)methyl chloride, dry AgNOg, and 1,2-dim ethoxy ethane vigorously stirred 2-4 hrs. at room temp, in a light-shielded flask -> 4-(4-chloro-2-nitrophenylcarbamoyl)morpholine. Y 90-95%. F. e., also p-rearrangement, s. W. Ried and W. Merkel, B. 105, 1532 (1972). 

This transformation can be achieved by deprotonation of the terminal alkyne (with NaNH2) and subsequent treatment with an appropriate electrophile (in this case the electrophile is CICH2OCH2CH2OCH3, called methoxy ethoxy methyl chloride or MEM chloride), followed by reduction of the alkyne group via hydrogenation. 

A variant on this structure, dioxyline, has much the same activity as the natural product but shows a better therapeutic ratio. Reduction of the oxime (113) from 3,4-dimethoxyphenyl-acetone (112) affords the veratrylamine homolog bearing a methyl group on the amine carbon atom (114). Acylation of this with 4-ethoxy-3-methoxyphenyl acetyl chloride gives the corresponding amide (115). Cyclization by means of phosphorus oxychloride followed by dehydrogenation over palladium yields dioxyline (116). ... 

FluorO-11/3-hydrOxy-16/3-methyl-170 .21-(r-ethyl-1 -ethoxy methylenedioxyipreg-na-1,4-dlene-3.20-dione Acetic Acid Propionyl Chloride... 

Reaction of /V,/V-unsubstituted selenoureas 332 with methyl vinyl ketone in the presence of ferric chloride in refluxing ethanol gives 2-amino-5-(l -ethoxy)-1,3-selenazoles 335 <06H(68)2145>. This approach obviates the use of lachrymatory halo carbonyl compounds frequently utilized in the synthesis of 1,3-selenazoles. 

N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropyl-N-methylpropan-2-aminium Iodide N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropylpropan-2-aminium Chloride N-(2-Chloroethyl)dimethylamine N-(2-Chloroethyl)-N,N-dimethylamine N-(2-Hydroxyethyl)diethylamine N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide N-(Diethylamino)ethanol N-(Isopropyl)-2-propamine... 

Acylation reactions can also be greatly improved in this way, with t-alkyl- or sec-alkyl-manganese reagents reacting with acid chlorides in excellent yields [123]. The related addition-elimination to 3-ethoxy-2-cyclohexenone is also improved, resulting after acidic aqueous workup in 3-methyl-2-cyclohexenone [125]. The perilla-ketone 126 was prepared in an improved yield using copper(I) catalysis (Scheme 2.58) [129]. 

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