Methyl acetanilid bromid

CLOGP calculations on benzyl bromide and o-methyl acetanilide. 

Fig. 12 24- CLOGP calculations on benzyl bromide and o-methyl acetanilide...

METHYL SULFOXIDE (67-68-5) CjHjOS (CHjIjSO Combustible liquid [explosion limits in air (vol %) 2.6 to 63.0 flashpoint 203°F/95°C oc autoignition temp 419°F/215°C Fire Rating 2]. Violent or explosive reaction with strong oxidizers, acryl halides, aryl halides and related compounds, alkali metals p-bromobenzoyl acetanilide, boron compounds, especially hydrides iodine pentafluoride, magnesium perchlorate, methyl bromide, perchloric acid, periodic acid, silver fluoride, sodium... 

The etherification of 4-mercaptoacetanilide with w-propyl bromide gives rise to the formation of 2-nitro-4 (propylthio) acetanilide with the elimination of one mole of HBr. The resulting product upon hydrolysis converts it to an amine, reduction with SnCl2 to a diamine, and finally interaction with S-methyl thiourea affords eyelization to yield carbamie aeid [5-(propylthio)-IH benzimidazol-2-amino]. This upon acetylation with methyl ehloroformate affords the offieial eompound albendazole. 

Another approach to achieve C-H acylations relies on synthesizing the carbonyl group in situ from seemingly unrelated precursors. Following this strategy, terf-butyl hydroperoxide can be used to oxidize benzylic methyl groups, which leads to C-H acylation of acetanilides in the presence of a Pd catalyst (Scheme 23.23). Remarkably, these reactions tolerate the presence of other benzyhc methyl groups as well as aryl bromides [87]. 

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