4 -Methoxyflavone

Hadj-Mahammed et al. analyzed a mixture of flavone, 5-methoxyflavone, and tangeretin by supercritical CO2 SFC on capillary columns with two types of detectors flame ionization (FID) and FT-IR. Peafe identification was achieved with the help of the FT-IR fingerprint of each compound. However, the separation was satisfactory only by the use of supercritical C02g density programs, without the use of a phase modifier. The separations were accomplished using a Carlo Erbaa SFC system equipped with a Model SFC 300 pump and Model SFC 3000 oven. The fused silica capillary column were BPl (12 mxO.l mm I.D. 0.1-pm film of di- methylpolysiloxane) and DB5 (15 mxO.l mm TD. 0.4-pm film of 94% dimethyl-, 5% diphenyl-, and 1% vinylpolysiloxane). The two supercritical CO2 density programs used in this work were PI [from 0.127 g/mIi->... 

A number of experimental studies have been performed looking at the gastroduodenal damaging effects of non-steroidal antiinflammatory drugs (NSAID) such as indomethacin [193]. In these studies, orally administered 5-methoxyflavone inhibited indomethacin-induced leukocyte adherence to mesenteric venules, suggesting a role of inhibition of leukocyte adherence in gastroprotective activity of this flavonic compound. 

Hydroxy-5-methoxyflavone, in D-20116 3-Hydroxy-7-methoxyflavone, in D-20117 5-Hydroxy-3-methoxyflavone, in D-20116... 

Figure 5. Betavulgavin (2 -hydroxy-6,7-methylenedioxy-5-methoxyisoflavone, 14), 2 ,5-dimethoxy-6,7-methylenedioxyflavanone (15), betavulgarin 2 -xyloside (16), betavulgarin 2 -gluoside (17), 6,7-methylenedioxy-5-methoxyflavone (18), 6,7-methylenedioxy-5-methoxydihydroflavonol (19) and 3 -methoxy-4 ,5,7-trihydroxy-dihydroflavonol (20).

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