12- Methoxy-N

The naphthalimide 11.23 is manufactured from acenaphthene by sulphonation, oxidation to the naphthalic anhydride derivative and conversion to 4-methoxy-N-methylnaphthal-imide as outlined in Scheme 11.14. 

Figure 12.10 Pyrogram of acrylic emulsion paints containing different organic pigments (a) PR5 (b) PR112 (c) PR4 (d) PY3 (e) PR 251 (f) PY74. Peak assignments 1, EA 2, MMA 3, nBA 4, 4 chloro 2 nitro benzenamine 5, 2 chloro benzenamine 6, 1 chloro 2 isocya nato benzene 7, 2 methoxy 4 nitro benzenamine 8, 2 methoxy benzenamine 9, 1 isocya nato 2 methoxy benzene 10, 1 chloro 4 nitro benzenamine 11,1 chloro 2 nitro benzene 12, 2 naphthalenol 13, 3 amino 4 methoxy N,N diethyl benzenesulfonamide 14, 4 meth oxy N,N diethyl benzenesulfonamide 15, 5 chloro 2,4 demethoxy benzenamine 16, 2,4,5 trichloro benzenamine 17, 1,3,4 trichloro benzene 18, 2 methyl benzenamine 19,...

Tab. 10.6 summarizes the application of this transformation to a variety of racemic secondary allylic carbonates using the lithium anion of 4-methoxy-N-(p-toluidine)-benzene sulfonamide. The excellent regioselectivity obtained for this type of substitution provided an important advance in the synthesis of N-(arylsulfonyl)anihnes using the metal-catalyzed allyhc amination reaction. The allyhc alcohol derivatives examined... 

Encainide Encainide, 4-methoxy-N-[2-[2-(l-methyl-2-piperidinyl)ethyl]phenyl]-benza-mide (18.1.15), is synthesized by acylating 2-(l-methyl-2-piperidylethyl)aniline with 4-methoxybenzoic acid chloride. The chemical structure of encainide is substantially different than other local anesthetics and antiarrhythmics [25-27]. 

TRYPTAMINE, N-ISOPROPYL-4-METHOXY-N-METHYL INDOLE, 3-[2-(ISOPROPYLMETHYLAMINO)ETHYL]-4-METHOXY N-ISOPROPYL-4-METHOXY-N-METHYLTRYPTAMINE 3-[2-(ISOPROPYLMETHYLAMINO)ETHYL]-4-METHOXYINDOLE... 

A suspension of 0.76 g LAH in 50 mL THF was stirred under an inert atmosphere, and treated with the dropwise addition of a solution of 2.5 g N-(benzyloxycarbonyl)-4-methoxytryptamine in 30 anhydrous THF. The reaction mixture was held at reflux for 30 min, then cooled to 40 °C and the excess hydride destroyed with the addition of 50% aqueous THF. The solids were removed by filtration, washed with THF, the filtrate and washings combined, and the solvent removed under vacuum. The residue, impure 4-methoxy-N-methyltryptamine, was dissolved in 50 mL ethanol, treated with 1.0 mL acetone, then with 0.5 g 10% Pd / C, and the reaction mixture shaken under a hydrogen atmosphere at 50 psi for 15 h. The catalyst was removed by filtration through a bed of Celite, the filtrate stripped of solvent under vacuum, and the solid residue recrystallized from Et20 / hexane to give 0.51 g 4-methoxy-N-methyl-N-isopropyltryptamine (4-MeO-MIPT) which had a mp 80-81 °C. Anal C15H22N20. C,H,N. MS (in m/z) C5H12N+ 86 (100%) indolemethylene+ 160 (4%) parent ion 246 (6 %). 

Methoxy-N -(pentafluoro-bcitzyli-dene)-letrafluoro- E10b2. 59 (Educt)... 

Methoxy-N-(2.2.2-trifluoro-ethylidene)- ElOb, 534/539f. (Educt)... 

A brief comment on two of the N,N-dimethylhomologues of methoxy-amphetamine. One was 4-methoxy-N,N-dimethylamphetamine, 4-MNNA. This material, made by the reductive animation of 4-methoxyphenylacctone with dimethylamine, was a colorless oil, which distilled at 70-85 °C at 0.3 mm/Hg. The corresponding 2-methoxy-N,N-dimethylamphetamine was similarly made. 2-MNNA was also a colorless oil and had the same bp. Both of them were fluorinated with l8F labelled acetyl hypofluorite (3% and 6% yields respectively) but neither of them was pursued any further in the search for a brain blood flow indicator. 

Chemical Name Benzamide, 4-methoxy-N-(2-(2-(l-methyl-2-piperidinyl) ethyl)phenyl)-, monohydrochloride... 

Dipipcridino-phenyl- E2, 482 Di-2-propinyloxy-ethyl- E2, 196 Dipropyl-(4-methoxy-N-lfaethyl-amlino)- E2, 296 Dipropyl-propyloxy- E2, 212 Divinyl-phenyl- E2 874 Ethoxy-ethyl-methoxycarbonylmethyl- E2, 21 Ethoxy-ethyl-phenyl- E2, 23 Ethoxy-hydroxy-methyl- E2, 130, 131 Ethoxy-hydroxy-phenyl- E2, 131, 185, 187, 190, 422 Ethoxy-(2-propinyloxy)-trifluormethyl- E2, 196 Ethyl-ethylthio-(l-methyl-3-oxo-butyl)- E2, 223 Ethyl-methyl-phenyl- -tosylimid E2, 11.3 Ethyl-pbenyl-propyloxy- E2, 281 F.thyl-phenyl-propylthio- E2, 225. Hydroxy-(2-isopropyl-5-methvl-cyclohexvloxv)-methyl- E2, 392... 

During total synthesis studies on ( )-3-deoxy-7,8-dihydromorphine and ( )-4-methoxy- N-methylmorphinan-6-one, a series of racemic mixtures with both 2- and 4-oxygen substituents (76) was isolated and characterized.(69) 2,4-Dihydroxy-3-methoxymorphinan-6-ones were isolated in an investigation of the Grewe codeine synthesis/78 ... 

Benzoyl-2,4-bis-[4-methoxy-phenyl]-l,3-thiazol(R =R2 = 4-OCHj—C6H5 R3 = CJ-I5)770 3,7 g (0,01 mol)4-Methoxy-N-(4-methoxy-a-morpholino-benzyliden)-thiobenzamidund 1,99 g(0,01 mol) oj-Brom-acetophe-non werden in 15 m/ Acetonitril gelost und anschlieBend mit 5 ml Triethylamin versetzt. Es wird kurz aufgekocht und nach dem Abkuhlen mit Wasscr vcrdunnt. Man saugt das farblose Endprodukt ab und kristallisiert aus Ethanol um Ausbeute 3,58 g (89%) Schmp. 149-150". 

BenZoylamino-thiocarbonyl)-ethoxycarbonyl-methyll-4-hydroxy- 8 2-Benzoyl-3-benzyl-5-ethoxycarbonyl-4-methyl-2,3-dihydro- 356 5-Benzoyl-2,4-bis-[4-methoxy-phcnyl]-aus 4-Methoxy-N-(4-methoxy-a-morpholino-bcnzyliden)-thio-benzamid und -Brom-aceto-phcnon 135 5-Benzoyl-2-chlor- 263... 

Amotriphene, 8-[Bis<4-melhoxyphenybmethylene]-4-methoxy-N, N-dimethylbenzeneethanamitte 2,3,3-tris(p-methoxyphenyi)-S,N-dimethytatlylamine 3 -dimethylamino-1,1,2 -tris(4 -methoxyphenyl) -1 -propene aminoxytriphene Win 5494 Myordil. CjjH NOj mol wt 403.50. C 77.39%,... 

Benzenesulfonamide, 4-methoxy-N-(5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl)- Benzenesulfon-amide, N-(5-isobutyl-1,3,4-... 

Methoxy-N-phenyl- benzenamine 4-CH30CsH4NHPh 85.1 355.9 Correlation 2000DEN/DEN... 

The benzylic position of 4-methoxy-n-propylbenzene has been substituted by the azido group in 97% yield through prolonged reaction over 5 days with excess trimethylsilylazide in chloroform containing 2,3-dichloro-... 

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