Methodology and Search Procedure

A solution space, a, consisting of hyperrectangles defined in the decision space, X, is a basic characteristic common to all the learning methodologies that will be described in subsequent sections. The same does not happen with the specific performance criteria tfi, mapping models /, and search procedures 5, which obviously depend on the particular nature of the systems under analysis, and the type of the corresponding performance metric, y. 

In the previous paragraphs we defined the solution format f, performance criterion i/r, mapping procedure /, and performance metric y that characterize our learning methodology for systems with a quantitative metric y. Here we will assemble all these pieces together and briefly discuss the search procedure, S (further details can be found in Saraiva... 

Below, the procedure for the determination of dominant campaigns in a version that was proposed by Lazaro et al. (1989) is outlined. Their methodology includes enumeration of feasible production sequences, selection of dominant production lines, task sequencing, and search for an optimum with constraints. All possible production variants are generated by an enumeration procedure that takes into account the possibility of available equipment working in parallel, initial and final task overlapping, and instability of intermediate products. Non-feasible sequences are eliminated so that only favourable candidates are subjected to full evaluation. Dominant production lines are selected by maximizing the criterion ... 

The first positive results in the synthesis of these heterocyclic compounds by MCR of aminoazoles, aldehydes, and barbituric acids were published in 2008 by Shi et al. [111]. They also used green chemistry methodology and carried out treatment of the starting materials in water under microwave irradiation. The temperature optimization procedure and search for the best catalytic system allowed selecting one equivalent of p-TSA and 140°C as optimum conditions for the synthesis. With application of the procedure elaborated 24 novel pyrazolopyr-idopyrimidines 76 were generated (Scheme 33). 

It is apparent that the use of enzymatic catalysis continues to grow Greater availabiUty of enzymes, development of new methodologies for thek utilization, investigation of enzymatic behavior in nonconventional environments, and the design and synthesis of new biocatalysts with altered selectivity and increased stabiUty are essential for the successhil development of this field. As more is learned about selectivity of enzymes toward unnatural substrates, the choice of an enzyme for a particular transformation will become easier to predict. It should simplify a search for an appropriate catalyst and help to estabhsh biocatalytic procedures as a usehil supplement to classical organic synthesis. 

No planning methodology can be efficient or credible for the synthesis of process operating procedures, if it focuses only on the search for the best plan, delegating the modeling needs and the articulation of the requisite constraints to inferior tasks. The reverse is also true. Consequently, a concise methodology for the synthesis of operating procedures should provide a unified treatment of all three pivotal components, namely... 

The most suitable analytical methodology should be selected based on the required performance characteristics. A sound literature search is always of great help with respect to known methods for the respective analyte and matrices. In most cases the search results will not directly provide the method wanted but will allow the most likely successful analytical approach to be set up. In this context, pre-considerations should address the most appropriate sample work-up procedure as well as the suitable analytical separation and detection system. The question of direct analysis of the analyte or a derivate formed after chemical reaction should be clarified. And finally, some thoughts should already be given to the question of chemical stability of the analyte in the given matrices under the applied conditions. 

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