Methodological Aspects on in vivo Intestinal Perfusion Techniques

Methodological Aspects on in vivo Intestinal Perfusion Techniques 

Clinical studies of effective intestinal permeability (Peff), secretion and metabolism of various compounds, such as drugs, environmental pollutants and nutrients are 

Assessing the effect of the intestinal metabolism in the Peff as a membrane transport rate parameter is a methodological issue [7, 26, 34, 35, 49]. An evaluation of its influence has to include a study to establish which enzyme(s) is (are) involved and the site of metabolism in relation to the site of the measurements. Intracellular metabolism in the enterocyte, for instance by CYP 3A4 and di- and tri- 

In vivo Permeability Studies in the Gastrointestinal Tract of Humans 

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Methodological Aspects on In-vivo Intestinal Perfusion Techniques... 

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