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Method yessotoxin

Three classes of polyethers, okadaic acid derivatives, pectenotoxins, and yessotoxin were isolated from bivalves in connection with diarrhetic shellfish poisoning. The etiology of the toxins, toxicological properties, and determination methods are described. [Pg.120]

Yessotoxin (214) is a polyether from the scallop Patinopecten yessoensis and has been implicated in diarrhetic shellfish poisoning (DSP). The structure and partial stereochemistry of yessotoxin were deduced from spectral data [219]. The relative stereochemistry of yessotoxin and the structures of two new analogues, 45-hydroxyyessotoxin (215) and 45,46,47-trinoryessotoxin (216) were also established [220]. The absolute stereochemistry of yessotoxin (214) was determined by NMR spectroscopy using a chiral anisotropic reagent [221]. The absolute configuration at C45 in 45-hydroxyyessotoxin (215), isolated from P. yessoensis, was determined by the use of a modified Mosher s method [222]. [Pg.653]

Takahashi, H., Kusumi, T, Kan, Y., Satake, M., and Yasumoto, T. 1996. Determination of the absolute configuration of yessotoxin, a polyether compound implicated in diarrhetic shellfish poisoning, by NMR spectroscopic method using a chiral anisotropic reagent, methoxy-(2-naphthyl)acetic acid. Tetrahedron Letters 37, 7087-7090. [Pg.201]

Pazos, M.I, Alfonso, A., Vieytes, M., Yasumoto, T, and Botana, L. 2004. Resonant mirror biosensor detection method based on yessotoxin-phosphodiesterase interactions. Analytical Biochemestry 335, 112—118. [Pg.208]

An extract of the digestive glands of P. yessoensis, collected fiom the aforementioned location, upon fractionation gave a new polyether toxin, yessotoxin[114]. The structure of which was determined by spectroscopic methods (92) and has the chemical characteristics of dinoflagellate toxins isolated from Gymnodinium breve (93). Recently, toxic mussels collected from Ban try Bay, Ireland, were found to contain dinophysistoxin-2 (DTX2) [115] (94). [Pg.20]

Yessotoxins (YTXs) represent a relatively new toxin class where methods of analysis have been required for integration into monitoring programs. In 2002, the EU set the regulatory Unfit for YTXs in shellfish whole flesh as 1 mg/kg expressed as the sum of YTX and homoyessotoxin plus their... [Pg.25]

Ramstad, H., Larsen, S., and Aune, T., Repeatability and validity of a fluorimetric HPLC method in the quantification of yessotoxin in blue mussels (Mytilus edulis) related to the mouse bioassay. Toxicon, 39,1393, 2001. [Pg.45]

A thorough study on extraction methods has been recently reported to selectively eliminate the effects of false positives caused by yessotoxins. ... [Pg.155]

Alfonso, C. et al., Extraction and cleaning methods to detect yessotoxins in contaminated mussels, Anal Biochem 363, 228, 2007. [Pg.158]

Alfonso, A. et al., A rapid microplate fluorescence method to detect yessotoxins based on their capacity to activate phosphodiesterases, Anal Biochem 326, 93, 2004. [Pg.159]

When using the mouse bioassay for detecting lipophihc marine biotoxins, false positives may occur due to the presence of other substances such as yessotoxins, pectenotoxins, and cychc imines, which are not know to cause human illness. When false positives are suspected, confirmatory testing, using an internationally vahdated method, can be carried out in order to identify the type(s) of marine biotoxins present. [Pg.928]


See other pages where Method yessotoxin is mentioned: [Pg.275]    [Pg.218]    [Pg.50]    [Pg.64]    [Pg.159]    [Pg.195]    [Pg.198]    [Pg.349]    [Pg.5]    [Pg.21]    [Pg.25]    [Pg.28]    [Pg.151]    [Pg.215]    [Pg.258]    [Pg.573]    [Pg.920]    [Pg.448]    [Pg.418]   
See also in sourсe #XX -- [ Pg.302 , Pg.305 ]




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