Method equivalency

Intervals were calculated using a method equivalent to rounding numbers to Integer values before assignment to Intervals. 

Borman, P. J., Chatfield, M. J., Damjanov, I., Jackson, P. Design and analysis of method equivalence Studies. Anal. Chem., 81, 2009,9849-9857. 

This method (EPA 1664) is a liquid-liquid extraction gravimetric procedure that employs n-hexane as the extraction solvent, in place of 1,1,2-trichloroethane (CFC-113) and/or 1,2,2-trifluoroethane (Freon-113), for determination of the conventional pollutant oil and grease. Because the nature and amount of material determined are defined by the solvent and by the details of the method used for extraction, oil and grease method-defined analytes are used. The method may be modified to reduce interferences and take advantage of advances in instrumentation provided that all method equivalency and performance criteria are met. However, n-hexane is a poor solvent for high-molecular-weight petroleum constituents (Speight, 1999, 2001). Thus, the method will produce erroneous data for samples contaminated with heavy oils. 

Lister, A., Method Equivalency, presented at PhRMA Meeting at Washington DC, September 2003. 

Chemometrican Data management and data fusion Process data analysis Multivariate data analysis Analyzer calibration model development Method equivalence Process models development (e.g., MSPC) Experimental design (e.g., DOE)... 

Define the method equivalence criteria or acceptance criteria. 

SC) CAS-SDCI is, in general, computationally heavier than ec-CCSD. A full dressing method (equivalent to SS-MRCC) would be much heavier. 

Equal volumes (1. iL) of standard and sample solutions were injected into the system and the amount present in the sample solution was calculated according to the HPLC method. Equivalent results were obtained from the HPLC and GC methods. If a product contains a lower concentration of Polysorbate 80 (e.g., lower than 0.05 g/kg), the GC method may be superior over the HPLC method. In such a case, derivatization and extraction steps may be required during sample preparation. The yield of oleic acid from hydrolysis of Polysorbate 80 was examined by analyzing a Polysorbate 80 spiked sample against an oleic acid standard. The calculation was based on the fact that 1 mol of polysorbate 80 releases 1 mol of oleic acid. 

The overall process of method validation is illustrated in Figure I. However, the extent and scope of validation is governed by the applicability of the method. An in-house procedure requires a less exacting process than a method intended for multi-matrix and/or multi-laboratory use. For the latter methods, a full collaborative trial is necessary and is covered in Chapter 9. However, for many purposes validation is limited to either demonstrating that method performance criteria established during development are met under routine laboratory conditions and/or showing method equivalence (Figure 18). 

The transfer process running in an information transfer channel K. is possible to be comprehended (modeled or, even, constructed) as the direct Carnot Cycle O [6, 8], The relation 0= K. is postulated. Further, we can imagine its observing method, equivalent to its mirror ... 

Very few Friedel-Crafts methods equivalent to the acylation with acyl halides or anhydrides are available to make formylation, undoubtly because halides and anhydrides of formic acids are very unstable. 

For the present purposes, a method equivalent to Ritchies may be used. 

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