Methicillin pharmacokinetics

This family is exemplified by moenomycin A 77, a major representative of moeno-mycin complex produced by S. ghanaensis (ATCC14672). Compound 77 is one of the most potent antibiotics known to date it is active against many vancomycin-and methicillin-resistant pathogens [141]. Moenomycin A suffers from poor pharmacokinetics, prompting the search for improved analogs that are suitable for treating human diseases. 

Sunakawa K, Nonoyama M, Fuji R, Iwai N, Sakata H, Shirai M, Sato T, Kajino M, Toyonaga Y, Sano T, Naito A, Minagawa K, Niida Y, Oda T, Yokozawa M, Asanuma H, Shimura K, Fujimura M, Kitajima H, Fujinami K, Numazaki K, Fujikawa T, Kobayashi Y, Sato Y, Nishimura T, Iwata S, Tsuchihashi N, Oishi T, Matsumoto S, Motohiro T, Osawa M, Sunahara M, Shirakawa S, Nishida H, Takahashi N, Nakano R, Sai N, lyoda K, Yoshimitsu K, Ogawa K, Okazaki T, Tsukimoto I, Motoyama O, Takada Y, Kawasaki M, Sunaoshi W, Nakamura S, Ueda Y, Kamata M, Kato T, Chiba M, Ouchi K, Sato S, Horiuchi T, Suzuki K, Shimoyama T, Masaki H, Aikyo M, Kawada M, Banba M, Furukawa S, Okada T, Yamaguchi S, Hirota O, Koizumi S, Wada H, Ohta K, Uehara T, Yukitake K, Mori T, Takakuwa S, Matsuyama K. [Pharmacokinetic and clinical studies on teicoplanin for sepsis by methicillin-cephem resistant Staphylococcus aureus in the pediatric and neonate field.] Jpn J Antibiot 2002 55(5) 656-77. 

Pharmacokinetics and ciinical use Mupirocin is used topically and is not absorbed. This drag is indicated for impetigo caused by staphylococci (including methicillin-resistant strains), beta-hemolytic streptococci, and Streptococcus pyogenes. It is also used in-tranasally to eliminate staphylococcal carriage by patients and medical personnel. 

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