Methane phosphonic acid

Phosphonic Acid Amino-phenyl-methan- E21e, 5725 [Nitron +... 

SULFICYLBIS (METHANE) (67-68-5) CjHjOS (CH3)2S0 Combustible liquid [explosion limits in air (vol %) 2.6 to 63.0 flashpoint 203°F/95°C oc autoignition temp 419°F/215°C Fire Rating 2]. Violent or explosive reaction with strong oxidizers, acryl halides, aryl halides and related compounds, alkali metals p-bromobenzoyl acetanilide, boron compounds, especially hydrides iodine pentafluoride, magnesium perchlorate, methyl bromide, perchloric acid, periodic acid, silver fluoride, sodium hydride, potassium permanganate. Forms powerfully explosive mixtures with metal salts of oxoacids [iron(III)nitrate, phosphonic acid, sodium perchlorate]. On small fires, use dry chemicals or COj extinguishers. 

Notable exceptions to this generalization, apart from the lack of activity towards derivatives of the phosphonic acids, are isopropyl- and / r/-butyl-phosphonic acids and ben-zylphosphonic acid (2-methylpropyl)phosphonic acid is cleaved to give very low yields of 2-methylpropene and 2-methylpropane Isotopically labelled (carbon or hydrogen) methylphosphonic acid affords methane possessing the identical distribution of the... 

Shi et al. [161-164] studied a different reaction of an array of triphenylmethane and triarylmethane derivatives such as alkanes, alkenes, alkynes, phosphonates, phosphonic acids and esters, dialkylamines, triaryl acetic acid, triaryl acetonitriles, triaryl acetates, and tetraarylmethanes and published a review of their work [65]. Mainly from product studies they proposed the special case of di-Jt-methane and oxa-di-7u-methane reactions [165], viz. a,a-elimination gives a biaryl and the corresponding carbenes and operates in polar and nonpolar sol-... 

Aminotrimethylolmethane. See Tris (hydroxymethyl) aminomethane Aminotri (methylphosphonic acid). See Aminotrimethylene phosphonic acid 2-Amino-1,3,5-trinitrobenzene 1-Amino-2,4,6-trinotrobenzene. See 2,4,6-Trinitroaniline Aminotris(hydroxymethyl) methane. See Tris... 

In addition, the Traer group also studied the proton-conducting dynamics of imidazole methylphosphonate. The P CODEX NMR showed that the rotation of the methylphosphonate has a low activation energy implying that the motion of the anion is not impeded by the sohd-state structure. P CODEX and variable temperature MAS NMR spectra confirmed that ionic conductivity is facihtated by dynamics at the bifurcated hydrogen bonds between anions, with a time scale of 57 4 ms at ambient temperature for rotation of the phosphonate about the C3V axis [51]. In the solid acid rubidium methane phosphonate (RMP) and the hydrated crystal RMP-2H20, they observed two different types of acidic protons as weU as the water protons in the lamella using H MAS NMR, and established... 

C17H17O3P, 3-(Benzyl(phenyl)phosphinyl)-2-butenoic acid, 44B, 625 Cl7H19CI2O5P, Diethyl bis(p-chlorophenoxy)methane-phosphonate, 46B, 675... 

Reactions and Properties of Phosphonic and Phosphinic Acids and their Derivatives.-A free radical mechanism has been proposed to account for the cleavage of the phosphorus-carbon bond in the alkylphosphonic acids (155) by E coli to give a mixture of alkane (methane only, from methylphosphonic acid) and terminal alkene. 

Synthesis of isomeric chiral protected (63 )-6-amino-hexahydro-2,7-dioxopyrazolo[l,2- ]pyrazole-l-carboxylic acid 280 is shown in Scheme 36. Crude vinyl phosphonate 275, obtained by treatment of diethyl allyloxycarbonylmethyl-phosphonate with acetic anhydride and tetramethyl diaminomethane as a formaldehyde equivalent, was used in the Michael addition to chiral 4-(f-butoxycarbonylamino)pyrazolidin-3-one 272. The Michael addition is run in dichloro-methane followed by addition of f-butyl oxalyl chloride and 2 equiv of Huning s base in the same pot to provide 276 in 58% yield. The allyl ester is deprotected using palladium catalysis to give the corresponding acid 277, which is... 

Alkyl esters of phosphonous and phosphinous acid also react readily y with carbon tetrachloride, while analogous aryl esters, e.g., EtP(OPh)2, are resistant even at 160° (152,173). The reaction of bromotrichloro-methane with triethyl phosphite, which occurs smoothly at 80° to furnish dialkyl trichloromethylphosphonate in excellent yield (99%), is light catalyzed. Chloroform is unchanged in the presence of triethyl phosphite (98,156) even under drastic conditions, and diethyl dichloro-methylphosphonate is not produced unless a free radical initiator is present (118). 

Benzylic Reactivity. 2,5-Dimethyl-3,4-dinitrothiophen has been condensed with aromatic aldehydes to give 3,4-dinitro-2,5-distyryl-thiophens. " An improved synthesis of 3-nitro-2-styryl-thiophens involves bromination of 3-methyl-2-nitrothiophen with A-bromosuccinimide, followed by a modified Wit-tig reaction. From 2,5-di(chloromethyl)thiophen, the phosphonate was prepared by the Arbusov reaction, which was used for the preparation of 2,5-distyryl-thiophens. Trichloromethyl(thienyl)carbinols have been converted into the corresponding fluoro-derivatives through the reaction with phenyl-tetrafluorophosphorane. The liquid-phase catalytic oxidation of phenyl-(2-thienyl)methane in acetic acid in the presence of cobalt(ll) acetate and sodium bromide has been investigated. ... 

In case of carboxylic acid starting materials, they were first converted into their corresponding acyl chlorides by reacting with oxalyl chloride in dichloromethane. A cooled dichloro-methane solution of an acyl chloride (1 1 mmol) in a 25 mL round bottomed flask was then added with triethylphosphite (1 mmol) drop-wise under stirring, and the reaction mixture was allowed to attain room temperature. On completion of the formation of acyl phosphonate, the reaction mixture was reduced in vacuo, and benzoic acid (2 mmol) was added directly to the residue, followed by benzene. The mixture was stirred to dissolve completely, then hydrazine solution in THF (1.05 mmol) was added drop-wise under rapid stirring. On completion of hydrazone formation, the reaction was flash-frozen and lyophilized. After lyophilization, 1 1 v/v tetrahydrofuran ferf-butanol was added to the flask and stirred to dissolve the solid. Potassium ferf-butoxide solution (3 mmol) in 1 1 v/v tetrahydrofuran ferf-butanol was then added to the stirring solution in one portion. After stirring at room temperature for several hours, the reaction was diluted with ethyl acetate (50 mL), quenched with 1 N HCl (20 mL), washed with saturated sodium bicarbonate (2 x 15 mL), then with brine (15 mL),... 

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