Methacrylated hyaluronic acid

Prata J E, Barth T A, Bencherif S A and Washburn N R (2010), Complex fluids based on methacrylated hyaluronic acid . Biomacromolecules, 11, 769-75. 

Oudshoom MHM, Rissmann R, Bouwstra JA, Hennink WE. Synthesis of methacrylated hyaluronic acid with tailored degree of substitution. Polymer. 2007 48 1915-20. 

Washburn, N. R. (2008) Influence of the degree of methacrylation on hyaluronic acid hydrogels properties. Biomaterials, 29, 1739-1749. 

Figure 8 Photopolymerizable hyaluronic acid (HA) derivatives modified with either (a) nonhydrolytically groups or (b-d) hydrolytically groups. Group abbreviations are as follows CL, caprolactone HEMA, hydroxyethyl methactylate LA, lactic acid Me, methacrylate.

Polymers carrying charged groups are referred to as polyelectrolytes. Poly(methacrylic acid) and poly(styrene sulfonate) are examples of industrial polyelectrolytes. Examples from nature are polynucleotides, proteins, and various polysaccharides such as pectin, chitin, hyaluronic acid, and so on. 

Diffusion coefficients of a variety of penetrants (such as methane, methanol, ethanol, benzaldehyde, acetophenone, benzoic acid, fluocinolone acetonide, etc) in PE, PDMS, poly(methyl methacrylate-co-hydroxyethyl methacrylate), and ethyl and benzyl esters of hyaluronic acid were calculated by Li and co-workers (327) using molecular dynamics. The main conclusions of their study were that the values of the diffusion coefficient predicted by the simulations showed reasonable agreement with the experimental data for systems containing hydrophobic penetrants and hydrophobic polymers. However, these numbers showed large disagreement when either the penetrant or the polymer was hydrophilic. This might be ascribed to force field inadequacies. The diffusion of both O2 and H2O in aqueous solutions of polyvinylpyrrolidinone at a variety of concentrations was studied by Eichinger and co-workers (328). 

Rossner M, Rossner F, Bachmann F, Wiest L, Rzany B. Risk of severe adverse reactions to an injectable filler based on a fixed combination of hydroxyethylmethacrylate and ethyl-methacrylate with hyaluronic acid. Dermatol Surg 2009 25(1) 367-74. 

Electrostatic Polyfstyrene sulfonate), polyallylamine hydrochloride, poly (diallyldimethyl ammonium chloride), polyethyleneimine, Nafion/Fe, poly (4-vinylpyridine), poly (acrylic acid), poly (methacrylic acid), poly (hydroxypropyl methacrylamide), polyferrocenylsillane [sulfonate] Poly(L-aspartic acid), poly(L-lysine) [imine formation], poly (L-arginine), albumin, protamine, silk proteins Dextran [sulfate], chitosan [quatemazied, sulfate], hyaluronic acid, alginate... 

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