Metformin healthy volunteers

Metformin XR uses a modified-release system to allow once-daily dosing. In 16 healthy volunteers aged 18-40... 

In a double-blind, randomized, crossover study in 12 healthy volunteers, cefalexin 500 mg increased the Cmax and AUC of a single dose of metformin 500 mg by 34 and 24% respectively and reduced its renal clearance to 14% (138). The authors suggested that cefalexin inhibits the renal tubular secretion of metformin. 

Gusler, G., et al. 2001. Pharmacokinetics of metformin gastric-retentive tables in healthy volunteers. 

Gusler, G., Gorsline, J., Levy, G., et al. Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers. J. Clin. Pharmacol. 41(6) 655-661, 2001. 

Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y. Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers. Drag Metabol Drag Interact 2002 19(l) 41-8. 

---